148890-53-3

Basic information

• Product Name: 4-FLUOROBENZYLISOCYANIDE
• Synonyms: 4-FLUOROBENZYLISOCYANIDE;1-FLUORO-4-(ISOCYANOMETHYL)BENZENE
• CAS NO: 148890-53-3
• Molecular Formula: C₈H₆FN
• Molecular Weight: 135.14
• Mol File: 148890-53-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FLUOROBENZYLISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZYLISOCYANIDE(148890-53-3)
• EPA Substance Registry System: 4-FLUOROBENZYLISOCYANIDE(148890-53-3)

Safety Data

• Hazardous Substances Data: 148890-53-3(Hazardous Substances Data)

Upstream product

• 84174-25-4 p-fluorobenzylamine formamide 
• 165806-95-1 1-((4-fluorophenyl)(isocyano)methylsulfonyl)-4-methylbenzene 
• 140-75-0 para-fluorobenzylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 1895-39-2 sodium chlorodifluoroacetate 
• 145181-97-1 [1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-(1H-tetrazol-5-yl)-amine 

Downstream Products

• 148858-14-4 5-tert-butyl-3-(4-fluorophenyl)-4,5-dihydroimidazo[1,5-a]quinoxalin-4-one 
• 1027037-42-8 6-Chloro-5-(3,4-dimethoxy-benzyl)-3-(4-fluoro-phenyl)-5H-imidazo[1,5-a]quinoxalin-4-one 
• 1026965-28-5 5-(3,4-Dimethoxy-benzyl)-7-fluoro-3-(4-fluoro-phenyl)-5H-imidazo[1,5-a]quinoxalin-4-one 
• 180207-96-9 7-Chloro-5-(3,4-dimethoxy-benzyl)-3-(4-fluoro-phenyl)-5H-imidazo[1,5-a]quinoxalin-4-one 

Relevant articles and documents

Anodic Oxidation of Aminotetrazoles: A Mild and Safe Route to Isocyanides

A new electrochemical method for the preparation of isocyanides from easily accessible aminotetrazole derivatives has been developed, which tolerates an unprecedented range of functional groups. The use of chemical, rather than electrochemical, oxidation to afford isocyanides was also demonstrated, which provides access to these compounds for those without electrosynthesis equipment. The practicality of scale-up using flow electrochemistry has been demonstrated, in addition to the possibility of using electrochemically generated isocyanides in further reactions.

SUBSTITUTED PYRROLIDINE AMIDES IV

The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

Synthesis of isocyanides by reacting primary amines with difluorocarbene

A general, convenient, and friendly route for preparing a versatile building block of isocyanides from primary amines is developed. Difluorocarbene, generated in situ from decarboxylation of chlorodifluoroacetate, reacts efficiently with primary amines to produce isocyanides. Various primary amines are well tolerated, including aryl, heteroaryl, benzyl, and alkyl amines, as well as amine residues in amino acids and peptides. Late-stage functionalization of biologically active amines is demonstrated, showing its practical capacity in drug design and peptide modification.