148893-10-1 Usage
Description
HATU, also known as 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate, is a widely used peptide coupling reagent in the field of organic chemistry. It is a white crystalline to off-white powder that facilitates the formation of amide bonds and is known for its efficiency in speeding up the coupling process while reducing the loss of chiral integrity.
Uses
Used in Pharmaceutical Industry:
HATU is used as a coupling reagent for peptide synthesis, which is crucial in the development of various pharmaceutical compounds. Its ability to speed up the coupling process and maintain chiral integrity makes it a valuable tool in the synthesis of complex peptide-based drugs.
Used in Research and Development:
HATU is employed as a reagent in the synthesis of Aurora A kinase inhibitors, which are important for studying the role of these enzymes in cellular processes and their potential as therapeutic targets.
Used in Analytical Chemistry:
HATU is utilized in the development of HPLC assays to determine Dand Lacid enantiomers in human plasma, which is essential for understanding the pharmacokinetics and pharmacodynamics of chiral drugs.
Used in Organic Chemistry:
HATU serves as a catalyst for selective acylation, selecocyclization-oxidation, and deselenation sequence reactions, which are vital for the synthesis of various organic compounds and materials.
Synthesis
The synthesis of HATU is as follows:The resulting residue treated with 2-Methoxycarbonylamino-3-methyl-butyric acid (60 mg, 0.343 mmol) and HATU (130 mg, 0.343 mmol), suspended in DMF (3 mL) and cooled to 0° C. DIPEA (0.272 mL, 1.56 mmol) was added dropwise. After stirring for 4 h, NaOH (5M in H2O, 0.300 mL, 1.5 mmol) was added. This mixture was stirred for 3 h then diluted with EtOAc and washed with 1 M LiOH (2*) then brine. The organic phase was dried over MgSO4, filtered and concentrated. The crude residue was then purified by HPLC to afford the title compound (53 mg, 44%).
Check Digit Verification of cas no
The CAS Registry Mumber 148893-10-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,8,9 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 148893-10:
(8*1)+(7*4)+(6*8)+(5*8)+(4*9)+(3*3)+(2*1)+(1*0)=171
171 % 10 = 1
So 148893-10-1 is a valid CAS Registry Number.
148893-10-1Relevant articles and documents
METHODS FOR TREATING HCV
-
, (2012/01/03)
This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.