148932-68-7 Usage
Description
2-Amino-3-methoxybenzonitrile is an organic compound with the molecular formula C8H8N2O. It is a versatile chemical intermediate that serves as a key building block in the synthesis of various pharmaceuticals and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
2-Amino-3-methoxybenzonitrile is used as a chemical intermediate for the preparation of cyclic guanidines, which act as dual 5-HT5A/5-HT7 receptor ligands. These ligands are important in the development of medications targeting neurological and psychiatric disorders, as they can modulate the activity of serotonin receptors, potentially leading to improved treatment options for conditions such as depression, anxiety, and schizophrenia.
Additionally, 2-Amino-3-methoxybenzonitrile is used as a starting material in the synthesis of 2and 3-aminobenzo[b]thiophenes. These compounds exhibit antimitotic properties, making them potential candidates for the development of anticancer drugs. By inhibiting the process of cell division, these agents can help in the treatment of various types of cancer, offering new therapeutic approaches to combat the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 148932-68-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,9,3 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 148932-68:
(8*1)+(7*4)+(6*8)+(5*9)+(4*3)+(3*2)+(2*6)+(1*8)=167
167 % 10 = 7
So 148932-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H8N2O/c1-11-7-4-2-3-6(5-9)8(7)10/h2-4H,10H2,1H3
148932-68-7Relevant articles and documents
Pyridyl Radical Cation for C?H Amination of Arenes
R?ssler, Simon L.,Jelier, Benson J.,Tripet, Pascal F.,Shemet, Andrej,Jeschke, Gunnar,Togni, Antonio,Carreira, Erick M.
supporting information, p. 526 - 531 (2019/01/04)
Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)?H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N?X pyridinium reagents mediated by visible light.
Structure-activity relationship of a series of phenylureas linked to 4- phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O- acyltransferase with antiatherosclerotic activity. 2
Kimura,Watanabe,Matsui,Hayashi,Tanaka,Ohtsuka,Saeki,Kogushi,Kabayashi,Akasaka,Yamagishi,Saitou,Yamatsu
, p. 1641 - 1653 (2007/10/02)
In our continuing search to find systemically bioavailable ACAT (acyl- CoA:cholesterol O-acyl-transferase) inhibitors with more potent antiatherosclerotic effect than N-[2-(dimethylamino)-6-[3-(5-methyl-4- phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N'-pentyl
