149022-22-0

Basic information

• Product Name: Amikacin sulfate salt
• Synonyms: AMIKACIN SULFATE 1:1.8;Amikacin sulfate salt;(2S)-4-AMino-N-{(1R,2S,3S,4R,5S)-5-aMino-2-[(3-aMino-3-deoxy-a-D-glucopyranosyl)oxy]-4-[(6-aMino-6-deoxy-a-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanaMide sulfate (1:2);AMIKASIN SULFATE;AMIKACIN SULFATE SALT, AMINOGLYCOSID;Amikacin sulfate(5:9)
• CAS NO: 149022-22-0
• Molecular Formula: C₂₂H₄₃N₅O₁₃*H₂O₄S
• Molecular Weight: 781.759
• EINECS: 254-648-6
• Mol File: 149022-22-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1102.4 °C at 760 mmHg
• Flash Point: 620.5 °C
• Appearance: white to off-white/
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble50mg/mL
• CAS DataBase Reference: Amikacin sulfate salt(CAS DataBase Reference)
• NIST Chemistry Reference: Amikacin sulfate salt(149022-22-0)
• EPA Substance Registry System: Amikacin sulfate salt(149022-22-0)

Safety Data

• WGK Germany: 2
• RTECS: WK1961200
• Hazardous Substances Data: 149022-22-0(Hazardous Substances Data)

Usage

Description

Amikacin sulfate salt, a derivative of the aminoglycoside antibiotic kanamycin, is a pharmaceutical compound with potent antibiotic properties. It is characterized by its ability to inhibit bacterial protein synthesis and is particularly effective against a range of gram-negative bacteria, including drug-resistant strains. Amikacin sulfate salt is known for its broad-spectrum activity and is often utilized in the treatment of severe infections when other antibiotics are ineffective.

Uses

Used in Pharmaceutical Industry:
Amikacin sulfate salt is used as an antibiotic for the treatment of various bacterial infections, particularly those caused by drug-resistant mycobacteria. Its application is crucial in combating severe infections that are resistant to conventional antibiotic treatments.
Used in Research and Development:
Amikacin sulfate salt is also utilized in the study of organism-directed delivery of antibiotics and the development of strategies to combat drug resistance. This application is vital in understanding the mechanisms of antibiotic resistance and the development of novel approaches to overcome it.

Biochem/physiol Actions

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.

InChI:InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1