14916-65-5 Usage
Description
5-Amino-2-nitropyridine is an organic compound with the molecular formula C5H5N3O2. It is a derivative of pyridine, a heterocyclic compound with a nitrogen atom in the ring structure. The presence of an amino group at the 5th position and a nitro group at the 2nd position gives this compound unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
5-Amino-2-nitropyridine is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its unique structure allows it to be a key building block in the synthesis of complex molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 5-Amino-2-nitropyridine serves as a valuable compound for studying the reactivity and properties of pyridine derivatives. It can be used to explore new reaction pathways and develop innovative synthetic methods.
Used in Preparation of Dihydroquinazoline Compounds:
5-Amino-2-nitropyridine is used as a key intermediate in the synthesis of dihydroquinazoline compounds, which are known as NAV1.8 inhibitors. These inhibitors have potential applications in the treatment of pain and other conditions related to the overactivation of the sodium channel, NAV1.8.
Check Digit Verification of cas no
The CAS Registry Mumber 14916-65-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,1 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14916-65:
(7*1)+(6*4)+(5*9)+(4*1)+(3*6)+(2*6)+(1*5)=115
115 % 10 = 5
So 14916-65-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N3O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H,6H2
14916-65-5Relevant articles and documents
SULFONAMIDE COMPOUNDS AND USES AS TNAP INHIBITORS
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Paragraph 00647, (2013/09/12)
Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper- mineralization.
Synthetic Approaches to some Aza-analogues of Benzimidazole N-Oxides. Part 1. The Imidazopyridine Series
Andrews, Adrian F.,Smith, David M.,Hodson, Harold F.,Thorogood, Peter B.
, p. 2995 - 3006 (2007/10/02)
The 3-oxide of 2-p-nitrophenylimidazopyridine (8) may be obtained in good yield by base-induced cyclisation of 2-nitro-3-(p-nitrobenzylamino)pyridine (18).It is also obtained in lower yield, along with p-nitrobenzoic acid and other cleavage products, by the corresponding reactions of bases with the N-ethoxycarbonyl, N-methylsulphonyl, and N-p-tolylsulphonyl derivatives of 2-nitro-3-(p-nitrobenzylamino)pyridine .Cleavage is the main reaction when N-(2-nitro-3-pyridyl)-N-phenacylmethanesulphonamide (17) is treated with bases: phenylglyoxal, or its Schiff base with 3-amino-2-nitropyridine, are possible intermediates in the cleavage process. 3-Nitro-2-(p-nitrobenzylamino)pyridine (31) is similarly cyclised in basic media to give the 1-oxide of 2-p-nitrophenylimidazopyridine (32).
