14919-77-8 Usage
Description
Benserazide hydrochloride, also known as a peripheral decarboxylase inhibitor, is a white crystalline solid that serves as an inhibitor of aromatic L-amino acid decarboxylase (AADC). It is an enzyme that has dopamine decarboxylase activity and is unable to cross the blood-brain barrier. Benserazide is often combined with L-DOPA in patients with Parkinson's disease, as it blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system, leading to an increase in the amount of L-DOPA reaching the central nervous system and reducing the required dose.
Uses
Used in Pharmaceutical Industry:
Benserazide hydrochloride is used as an antiparkinsonian agent for its role as a peripheral decarboxylase inhibitor. It is particularly effective in combination with L-DOPA, enhancing the treatment of Parkinson's disease by increasing the amount of L-DOPA reaching the central nervous system and reducing the required dose.
Additionally, Benserazide hydrochloride serves as an inhibitor of tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH), further contributing to its antiparkinsonian properties.
Biochem/physiol Actions
Inhibitor of L-aromatic amino acid decarboxylase.
Check Digit Verification of cas no
The CAS Registry Mumber 14919-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,1 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 14919-77:
(7*1)+(6*4)+(5*9)+(4*1)+(3*9)+(2*7)+(1*7)=128
128 % 10 = 8
So 14919-77-8 is a valid CAS Registry Number.
