149231-66-3

Basic information

• Product Name: AC-YVAD-PNA
• Synonyms: AC-TYR-VAL-ALA-ASP-PNA;N-ACETYL-TYR-VAL-ALA-ASP-P-NITROANILIDE PNA;N-acetyl-tyr-val-ala-asp P-nitroanilide;REF DUPL: Ac-Tyr-Val-Ala-Asp-pNA;N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine;CASPASE-1 SUBSTRATE IV, COLORIMETRIC;CASPASE-1 SUBSTRATE (CHROMOGENIC);CASPASE 1 (ICE) SUBSTRATE 2, CHROMOGENIC
• CAS NO: 149231-66-3
• Molecular Formula: C29H36N6O10
• Molecular Weight: 628.63
• Product Categories: Peptide;Caspase/Related Products;Pepetides
• Mol File: 149231-66-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1108.9±65.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.362±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 4.04±0.10(Predicted)
• CAS DataBase Reference: AC-YVAD-PNA(CAS DataBase Reference)
• NIST Chemistry Reference: AC-YVAD-PNA(149231-66-3)
• EPA Substance Registry System: AC-YVAD-PNA(149231-66-3)

Safety Data

• Hazardous Substances Data: 149231-66-3(Hazardous Substances Data)

Usage

Description

AC-YVAD-PNA is a synthetic peptide substrate designed for the study of caspases, a family of cysteine proteases involved in the regulation of apoptosis and inflammation. The sequence of amino acids YVAD within this substrate is particularly favored for cleavage by caspase-1 and -4, making it a valuable tool for researchers investigating the activity and function of these enzymes.

Uses

Used in Pharmaceutical Research:
AC-YVAD-PNA is used as a substrate for studying the activity of caspase-1 and -4 in various research applications. The expression is: AC-YVAD-PNA is used as a substrate for [application reason], which is to investigate the activity and function of caspase-1 and -4 in the regulation of apoptosis and inflammation.
Used in Drug Development:
AC-YVAD-PNA is used as a tool in the development of new drugs targeting caspases, particularly caspase-1 and -4. The expression is: AC-YVAD-PNA is used as a tool for [application reason], which is to aid in the development of therapeutic agents that modulate the activity of caspase-1 and -4, potentially leading to treatments for conditions involving dysregulated apoptosis or inflammation.
Used in Diagnostics:
AC-YVAD-PNA can be employed as a diagnostic marker to assess the activity of caspase-1 and -4 in patient samples, which may be useful in the evaluation of certain diseases or conditions. The expression is: AC-YVAD-PNA is used as a diagnostic marker for [application reason], which is to evaluate the activity of caspase-1 and -4 in patient samples, potentially providing insights into disease progression or response to treatment.
Used in Cell Biology Research:
AC-YVAD-PNA is used as a research tool to study the role of caspase-1 and -4 in cellular processes, such as apoptosis and inflammation, in cell biology research. The expression is: AC-YVAD-PNA is used as a research tool for [application reason], which is to investigate the role of caspase-1 and -4 in cellular processes, contributing to a better understanding of their functions in health and disease.