149246-80-0 Usage
Description
3-Amino-5-(2-bromophenyl)-1H-pyrazole is a pyrazole derivative with the molecular formula C9H8BrN3, featuring an amino group and a bromophenyl group. This chemical compound holds potential in pharmaceutical research and drug development due to its distinctive structure and properties.
Uses
Used in Pharmaceutical Research:
3-Amino-5-(2-bromophenyl)-1H-pyrazole is used as a building block for the synthesis of new drugs, leveraging its unique structure to create novel pharmaceutical agents.
Used in Drug Development:
It serves as a reference compound for analytical testing in the development of new medications, aiding in the assessment of drug efficacy and safety.
Used in Biological Activity Studies:
3-Amino-5-(2-bromophenyl)-1H-pyrazole is utilized in research to explore its potential biological activity, which may contribute to the discovery of new therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 149246-80-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,2,4 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 149246-80:
(8*1)+(7*4)+(6*9)+(5*2)+(4*4)+(3*6)+(2*8)+(1*0)=150
150 % 10 = 0
So 149246-80-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BrN3/c10-7-4-2-1-3-6(7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)
149246-80-0Relevant articles and documents
Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors
Kim, Ikyon,Song, Jong Hwan,Park, Chang Min,Jeong, Joon Won,Kim, Hyung Rae,Ha, Jin Ryul,No, Zaesung,Hyun, Young-Lan,Cho, Young Sik,Sook Kang, Nam,Jeon, Dong Ju
scheme or table, p. 922 - 926 (2010/06/22)
Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).
Methods of treating conditions associated with an EDG-4 receptor
-
, (2008/06/13)
The present invention provides a method of modulating an Edg-4 receptor mediated biological activity in a cell. A cell expressing the Edg-4 receptor is contacted with a modulator of an Edg-4 receptor sufficient to modulate the Edg-4 receptor mediated biol
