149274-04-4Relevant articles and documents
Enantioselective synthesis of (R)-phenylephrine hydrochloride
Pandey, Rajesh Kumar,Upadhyay, Puspesh Kumar,Kumar, Pradeep
, p. 6245 - 6246 (2003)
An efficient method for the synthesis of enantiomerically pure (R)-phenylephrine hydrochloride 1 is described using a Sharpless asymmetric dihydroxylation as the key step.
The kulinkovich reaction in the synthesis of constrained N,N-dialkyl neurotransmitter analogues
Faler, Catherine A.,Joullie, Madeleine M.
, p. 1987 - 1990 (2008/02/02)
An intermolecular Ti(IV)-mediated cyclopropanation reaction has been used to synthesize substituted 2-phenylcyclopropylamines and constrained analogues of the neurotransmitters histamine and tryptamine. Many hydroxy- and methoxy-substituted phenylcyclopropylamines are known to inhibit monoamine oxidase and have been shown to mimic hallucinogens. These compounds were made in 1 to 5 steps from readily available starting materials.
