14933-25-6

Basic information

• Product Name: 3-Chloro-4-hydroxy-1H-quinolin-2-one
• Synonyms: 3-CHLORO-4-HYDROXY-1H-QUINOLIN-2-ONE;3-CHLORO-4-HYDROXY-2-QUINOLONE
• CAS NO: 14933-25-6
• Molecular Formula: C₉H₆ClNO₂
• Molecular Weight: 195.6
• Mol File: 14933-25-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 284.6°C at 760 mmHg
• Flash Point: 126°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.00138mmHg at 25°C
• Refractive Index: 1.681
• CAS DataBase Reference: 3-Chloro-4-hydroxy-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-hydroxy-1H-quinolin-2-one(14933-25-6)
• EPA Substance Registry System: 3-Chloro-4-hydroxy-1H-quinolin-2-one(14933-25-6)

Safety Data

• Hazardous Substances Data: 14933-25-6(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-hydroxy-1H-quinolin-2-one is a chemical compound with the molecular formula C9H6ClNO2. It is a synthetic heterocyclic compound and a chlorinated derivative of 4-hydroxyquinoline. 3-Chloro-4-hydroxy-1H-quinolin-2-one is commonly used as an intermediate in the synthesis of pharmaceuticals and fine chemicals. It has also been studied for its potential biological activities such as anti-inflammatory, antifungal, and anticancer properties. Additionally, 3-Chloro-4-hydroxy-1H-quinolin-2-one has been used as a building block for the development of new drugs and agrochemicals due to its versatile reactivity and pharmacological potential.

InChI:InChI=1/C9H6ClNO2/c10-7-8(12)5-3-1-2-4-6(5)11-9(7)13/h1-4H,(H2,11,12,13)

Upstream product

• 86795-52-0 2-Oxo-3-phenyliodonium-1,2-dihydrochinolin-4-olat 
• 70254-43-2 4-Hydroxy-2-quinolone 

Downstream Products

• 110216-98-3 3-Chlor-4-tosyloxy-2(1H)-chinolon 
• 40335-02-2 2,3,4-trichloroquinoline 
• 3568-33-0 3,3-Dihydroxy-2,4-dioxo-1,2,3,4-tetrahydro-chinolin 

Relevant articles and documents

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Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids

The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones