149366-79-0

Basic information

• Product Name: 3-Boc-aminomethylpyrrolidine
• Synonyms: PYRROLIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER;3-(BOC-AMINOMETHYL)PYRROLIDINE;(3-PYRROLIDINYLMETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;3-N-BOC-AMINOMETHYL PYRROLIDINE ;3-(tert-Butoxycarbonylaminomethyl)pyrrolidine;3-BOCAMINOMETHYLPYRROLIDINE 98%;Carbamic acid, N-(3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester;3-(Boc-aminomethyl)pyrrol...
• CAS NO: 149366-79-0
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: pharmacetical;Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 149366-79-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 303.9 °C at 760 mmHg
• Flash Point: 137.6 °C
• Appearance: /
• Density: 0.997 g/cm³
• Vapor Pressure: 0.000902mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.71±0.46(Predicted)
• CAS DataBase Reference: 3-Boc-aminomethylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Boc-aminomethylpyrrolidine(149366-79-0)
• EPA Substance Registry System: 3-Boc-aminomethylpyrrolidine(149366-79-0)

Safety Data

• Hazardous Substances Data: 149366-79-0(Hazardous Substances Data)

Usage

General Description

3-Boc-aminomethylpyrrolidine is a organic compound with the molecular formula C11H20N2O2. It is a white powder that is commonly used as a pharmaceutical intermediate, particularly in the synthesis of various medications. This chemical is also known for its applications in medicinal chemistry as a building block for the production of biologically active compounds. Additionally, 3-Boc-aminomethylpyrrolidine has been studied for its potential role in drug discovery and development, making it a valuable and versatile chemical in the field of pharmaceutical research.

InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-7-8-4-5-11-6-8/h8,11H,4-7H2,1-3H3,(H,12,13)

Upstream product

• 155497-10-2 (1-benzyl-pyrrolidin-3-ylmethyl)-carbamic acid tert-butyl ester 
• 172477-98-4 1-benzyl-3-<(t-butyloxycarbonyl)methylamino>-pyrrolidine 

Downstream Products

• 582325-52-8 (1-benzoyl-pyrrolidin-3-ylmethyl)-carbamic acid tert-butyl ester 
• 802983-63-7 1-(3,3-diphenyl-propionyl)-pyrrolidin-3-ylmethyl carbamic acid tert-butyl ester 
• 802983-61-5 N-[1-benzhydryl]-3-aminomethyl-3-tert-butoxycarbonylpyrrolidine 
• 802983-59-1 {1-[6,6-bis-(4-fluoro-phenyl)-hexanoyl]-pyrrolidin-3-ylmethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors

We previously reported the small organic N-type calcium channel blocker NP078585 that while efficacious in animal models for pain, exhibited modest L-type calcium channel selectivity and substantial off-target inhibition against the hERG potassium channel

3-AMINOMETHYL-PYRROLIDINES AS N-TYPE CALCIUM CHANNEL BLOCKERS

The invention relates to compounds that are derivatives of 3-aminomethyl-pyrrolidine of the formulas: wherein: Y is (X2)1A or (X1)mCR4A2; W is CR4 or N; R1-R4 are noninterfering substituents; n is 0-7; 1 and m are independently 0 or 1; X1-X2 are linkers;

BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES USEFUL AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR THEIR USE

The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.