149376-70-5 Usage
Description
2-Amino-6-chloro-9H-purine-9-acetic acid is a purine derivative, which is an organic compound belonging to the class of purines. It is characterized by its unique chemical structure that features a 6-chloro substitution and an acetic acid group at the 9-position of the purine ring.
Uses
Used in Pharmaceutical Industry:
2-Amino-6-chloro-9H-purine-9-acetic acid is used as a starting material for the synthesis of various purine intermediates and derivatives. These synthesized compounds have potential applications in the development of new drugs and therapeutic agents.
2-Amino-6-chloro-9H-purine-9-acetiс acid is used as a building block for the creation of:
6-decyloxy substituted purine intermediates, which can be utilized in the development of drugs targeting specific biological pathways.
6-decylthio substituted purine intermediates, offering a different set of properties and potential applications in drug discovery.
6-decyloxy or 6-decylthio-9-phenylalanine/serine or alanine-substituted purine derivatives, which may have unique biological activities and could be used in the treatment of various diseases.
2,6-diaminopurine monomer, which can be used in the synthesis of nucleic acid analogs and other related compounds with potential applications in gene therapy and antiviral drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 149376-70-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,3,7 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 149376-70:
(8*1)+(7*4)+(6*9)+(5*3)+(4*7)+(3*6)+(2*7)+(1*0)=165
165 % 10 = 5
So 149376-70-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClN5O2/c8-5-4-6(12-7(9)11-5)13(2-10-4)1-3(14)15/h2H,1H2,(H,14,15)(H2,9,11,12)
149376-70-5Relevant articles and documents
Screening of Minimalist Noncanonical Sites in Duplex DNA and RNA Reveals Context and Motif-Selective Binding by Fluorogenic Base Probes
Bong, Dennis,Devari, Shekaraiah,Gonzalez, Maricarmen,Liang, Yufeng,Mao, Jie,Miao, Shiqin
supporting information, (2021/12/09)
We hypothesize that programmable hybridization to noncanonical nucleic acid motifs may be achieved by macromolecular display of binders to individual noncanonical pairs (NCPs). As each recognition element may individually have weak binding to an NCP, we d
Synthesis and biophysical properties of (l)-aTNA based G-quadruplexes
Kumar, Vipin,Gothelf, Kurt V.
supporting information, p. 1540 - 1544 (2016/02/10)
Novel G-quadruplex structures are constructed by acyclic (l)-threninol nucleic acid and their synthesis and biophysical properties are described. Pyrene excimer fluorescence and circular dichroism (CD) data revealed that four strands of aTNA are oriented
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
-
, (2008/06/13)
A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.