149560-32-7

Basic information

• Product Name: 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate]
• Synonyms: 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate]
• CAS NO: 149560-32-7
• Molecular Weight: 538.454
• Mol File: 149560-32-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate](CAS DataBase Reference)
• NIST Chemistry Reference: 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate](149560-32-7)
• EPA Substance Registry System: 3'-azidothymidine 5'-[p-methoxyphenyl methoxyalaninyl phosphate](149560-32-7)

Safety Data

• Hazardous Substances Data: 149560-32-7(Hazardous Substances Data)

Upstream product

• 879688-27-4 C₁₇H₂₀N₅O₇P 
• 10065-72-2 L-Alanine methyl ester 
• 150-76-5 4-methoxy-phenol 
• 147907-38-8 (4‐methoxy)phenyl (methoxy‐L‐alaninyl)phosphorochloridate 
• 209214-06-2 3'-azido-3'-deoxythymidine-5'-methoxyalaninyl phosphate 
• 20464-68-0 4-methoxyphenyl phosphorodichloridate 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 135263-41-1 p-methoxyphenyl phosphorodichloridite 

Downstream Products

• 150-76-5 4-methoxy-phenol 
• 244127-85-3 2(S)-(3-deoxy-3-azidothymidyl(hydroxy)phosphorylamino)propionic acid methyl ester 

Relevant articles and documents

Cytotoxic nucleoside analog compound 003 for treating cancer

The present invention provides pharmaceutical compositions comprising Compound 003 or metabolites thereof in combination with one or more carboxylesterase inhibitors. The invention provides methods for inhibiting cellular proliferation associated with pro

Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT

Novel aryl phosphate derivatives of the anti-HIV nucleoside analogue AZT have been prepared by phosphorochloridate chemistry. These materials were designed to act as membrane-soluble prodrugs of the bioactive free nucleotides. In vitro evaluation revealed the compounds to have a pronounced, selective anti-HIV activity in CEM cells; the magnitude of the biological effect varied considerably depending on the nature of the phosphate blocking group. Moreover, several of the compounds retain marked antiviral activity in TK- (thymidine kinase-deficient) mutant CEM cells in which AZT was virtually inactive. These data strongly support the hypothesis that the AZT phosphate derivatives exert their biological effects via intracellular release of AZT nucleotide forms and suggest that the potential of nucleoside drugs in antiviral chemotherapy may be enhanced by suitable nucleotide delivery strategies.