1496-36-2

Basic information

• Product Name: 1-(4-fluorophenyl)cyclohexanol
• CAS NO: 1496-36-2
• Molecular Formula: C₁₂H₁₅FO
• Molecular Weight: 194.2453
• Mol File: 1496-36-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 291.4°C at 760 mmHg
• Flash Point: 146.8°C
• Density: 1.14g/cm³
• Vapor Pressure: 0.000898mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 1-(4-fluorophenyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)cyclohexanol(1496-36-2)
• EPA Substance Registry System: 1-(4-fluorophenyl)cyclohexanol(1496-36-2)

Safety Data

• Hazardous Substances Data: 1496-36-2(Hazardous Substances Data)

Usage

Description

1-(4-fluorophenyl)cyclohexanol is a chemical compound with the molecular formula C12H15FO, characterized by a cyclohexanol ring with a fluorophenyl group attached. This white crystalline solid is frequently utilized in organic synthesis and pharmaceutical research, serving as a precursor for the development of various pharmaceuticals and biologically active compounds.

Uses

Used in Pharmaceutical Research:
1-(4-fluorophenyl)cyclohexanol is used as a precursor in the synthesis of pharmaceuticals for its potential in creating biologically active compounds.
Used in Organic Synthesis:
1-(4-fluorophenyl)cyclohexanol is used as a key intermediate in organic synthesis, contributing to the development of a wide range of chemical products.
Used in Medical Research:
1-(4-fluorophenyl)cyclohexanol is used as a research compound for its analgesic and anti-inflammatory properties, making it valuable in the exploration of new treatments within the medical industry.

Upstream product

• 108-94-1 cyclohexanone 
• 352-13-6 4-flourophenylmagnesium bromide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 108-93-0 cyclohexanol 
• 448-59-9 tris(4-fluorophenyl)boroxine 

Downstream Products

• 17380-57-3 N-[1-(4-fluoro-phenyl)-cyclohexyl]-formamide 
• 1546-11-8 4'-fluoro-2,3,4,5-tetrahydro-1,1'-biphenyl 
• 17380-80-2 1-(4-Fluor-phenyl)-cyclohexylamin 
• 1717-84-6 1-cyclohexyl-4-fluorobenzene 
• 1338349-24-8 N-(1-benzylpiperidin-4-yl)-2-[1-(4-fluorophenyl)cyclohexyl]acetamide 
• 1338349-21-5 3-[1-(4-fluorophenyl)cyclohexyl]propane-1,2-diol 
• 1225477-99-5 [1-(4-fluorophenyl)cyclohexyl]acetic acid 
• 1338349-22-6 [1-(4-fluorophenyl)cyclohexyl]acetaldehyde 
• 1338349-20-4 1-(1-allylcyclohexyl)-4-fluorobenzene 
• 111945-91-6 4'-fluoro-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 
• 324-74-3 4-fluoro-biphenyl 
• 188973-61-7 6-bromo-1-(4-fluorophenyl)-1-hexanone 
• 456-22-4 4-Fluorobenzoic acid 
• 1426-70-6 1-(4-fluorophenyl)-1-hexanone 

Relevant articles and documents

Rhodium(I)/diene-catalyzed addition reactions of arylborons with ketones

Rh(I)/diene-catalyzed addition reactions of arylboroxines/arylboronic acids with unactivated ketones to form tertiary alcohols in good to excellent yields are described. By using C2-symmetric (3aR,6aR)-3,6-diaryl-1,3a,4,6a- tetrahydropentalenes as ligands, the asymmetric version of such an addition reaction, with up to 68% ee, was also realized.

Synthesis and application of 2,6-bis(trifluoromethyl)-4-pyridyl phosphanes: The most electron-poor aryl phosphanes with moderate bulkiness

The poor will be rich: BFPy phosphanes (see scheme) mimic the electronic and steric characters of P(C6F5)3 and PPh 3, respectively. These novel ligands showed a large ligand acceleration effect on Stille coupling, the Rh-catalyzed 1,2-addition of aryl boronic acid to unactivated ketones and the asymmetric arylation of N-tosylimine using phenylboronic acid. Copyright

Synthesis and Anticonvulsant Activity of 1-Phenylcyclohexylamine Analogues

Thirty-eight analogues of 1-phenylcyclohexylamine (PCA), a phencyclidine (PCP) derivative, were examined for their activities in the mouse maximal electroshock (MES) seizure test and in a motor-toxicity assay.In addition, we determined the binding affinities of the compounds for PCP acceptor sites in rat brain membranes labeled with -1-piperidine.Many of the analogues were protective against MES seizures (ED50s of 4-41 mg/kg, ip) and all of these compounds caused motor toxicity.The potencies in the motor toxicity and MES seizure tests showed a moderate correlation with the affinities for PCP sites.Several analogues exhibited a greater separation of potencies in the motor toxicity and MES seizure tests than did the parent compound PCA.These were obtained by (i) 3-methylation of the cyclohexyl ring trans to the phenyl ring, (ii) methoxylation at the ortho position on the phenyl ring, and (iii) contraction of the cyclohexane ring to form the corresponding cyclopentane.