149865-91-8

Basic information

• Product Name: 2-aMino-N,N-diMethyl-2-phenylacetaMide
• Synonyms: BenzeneacetaMide, α-aMino-N,N-diMethyl-, (αS)-;(S)-2-amino-N,N-dimethyl-2-phenylacetamide
• CAS NO: 149865-91-8
• Molecular Formula: C10H14N2O
• Molecular Weight: 178
• EINECS: -0
• Mol File: 149865-91-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 306.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.086±0.06 g/cm3(Predicted)
• PKA: 7.31±0.10(Predicted)
• CAS DataBase Reference: 2-aMino-N,N-diMethyl-2-phenylacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-N,N-diMethyl-2-phenylacetaMide(149865-91-8)
• EPA Substance Registry System: 2-aMino-N,N-diMethyl-2-phenylacetaMide(149865-91-8)

Safety Data

• Hazardous Substances Data: 149865-91-8(Hazardous Substances Data)

Usage

Physical state

White to off-white crystalline powder

Solubility

Soluble in organic solvents

Uses

Synthesis of pharmaceuticals, building block in production of organic compounds, reagent in chemical reactions, research tool in organic chemistry

Pharmacological effects

Exhibits some pharmacological effects and being investigated for potential therapeutic applications

Safety

Handle with caution as it may have potential health and safety hazards.

Upstream product

• 129157-06-8 (R)-2-(t-butoxycarbonylamino)-N,N-dimethyl-2-phenylethanamide 
• 190442-36-5 ((R)-Dimethylcarbamoyl-phenyl-methyl)-carbamic acid benzyl ester 
• 17609-52-8 Z-D-phenylglycine 
• 33125-05-2 Boc-D-Phg-OH 
• 199928-80-8 2-Azido-N,N-dimethyl-2-phenyl-acetamide 
• 394734-93-1 (S)-benzyl 2-(dimethylamino)-2-oxo-1-phenylethylcarbamate 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 
• 506-59-2 N,N-dimethylammonium chloride 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 

Relevant articles and documents

A class of α-amino acids-derived multifunctional amidophosphane precatalysts: application to the highly enantio- and diastereoselective silver(I)-catalyzed 1,3-dipolar cycloaddition reaction

A class of multifunctional amidophosphanes derived from chiral α-amino acids have been developed with two amide bonds, a tertiary amine and a phosphine. In combination with Ag(I) salts, these amidophosphanes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides as well as the three-component reaction of the α-iminoesters in situ generated. Under optimal conditions, highly functionalized endo-8 pyrrolidines were obtained with good to excellent yields (up to 99% yield) and enantioselectivities (up to 98% ee).

CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS

Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase inhibitors, including as inhibitors of PAK4.

PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS

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