15000-41-6Relevant articles and documents
4-HYDROXY-2-QUINOLONES. 1. EFFICIENT METHOD FOR OBTAINING 3-ALKYL-4-HYDROXY-2-QUINOLONES
Bezuglyi, P.A.,Ukrainets, I.V.,Treskach, V.I.,Turov, A.V.
, p. 1237 - 1238 (1991)
3-Alkyl-4-hydroxy-2-quinolones were obtained in high yields via the Dieckmann intramolecular condensation of substituted malonic acid ethyl ester 2-carbalkoxyanilides.
One-step Synthesis of 3-Unsubstituted 4-Hydroxy-2(1H)-Quinoline
Menglin, Ma,Qingrong, Sun,Weiqing, Yang,Xingyi, Wang,Yinan, Xu
, p. 435 - 441 (2021/11/22)
3-Unsubstituted 4-hydroxy-2(1H)-quinolone (DHQ) derivatives were synthesized from aniline derivatives and diethyl malonate at low temperature using AlCl3 as catalyst and Eaton reagent as acidic environment. A reaction mechanism was proposed and elucidated. Different synthetic intermediates are specially prepared or purified and used to understand the reaction and validation mechanism.
3-Methylene-2,4-chromandione in situ trapping: Introducing molecular diversity on 4-hydroxycoumarin
Montagut-Romans, Adrien,Boulven, Manon,Lemaire, Marc,Popowycz, Florence
, p. 4540 - 4544 (2016/01/29)
3-Methylene-2,4-chromandione trapped in a solid-state stable Mannich adduct, is released in solution. In the presence of different nucleophiles, this highly reactive intermediate allows the introduction of molecular diversity on C-3 position of 4-hydroxycoumarin.