150020-64-7

Basic information

• Product Name: 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE
• Synonyms: 6-CHLOROIMIDAZO[2,1-B]THIAZOLE-5-SULFONYL CHLORIDE;6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE;BUTTPARK 37\12-52;6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulphonyl chloride;6-Chloroimidazo[2,1-b]thiazole-5-sulfonyl
• CAS NO: 150020-64-7
• Molecular Formula: C₅H₂Cl₂N₂O₂S₂
• Molecular Weight: 257.12
• Product Categories: Heterocycles
• Mol File: 150020-64-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 137 °C
• Appearance: /
• Density: 2.05 g/cm³
• Refractive Index: 1.817
• PKA: -5.33±0.40(Predicted)
• Water Solubility: Sparingly soluble in water.(0.26 g/L) (25°C),
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE(150020-64-7)
• EPA Substance Registry System: 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE(150020-64-7)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: 8
• Hazardous Substances Data: 150020-64-7(Hazardous Substances Data)

Usage

Description

6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE is a chemical compound with the molecular formula C?H?ClN?OS?. It is a derivative of imidazo[2,1-b][1,3]thiazole, featuring a chloro and a sulfonyl chloride functional group. 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE is known for its reactivity and is commonly utilized in the synthesis of various pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Industry:
6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE is used as a pharmaceutical intermediate for the synthesis of various drugs and bioactive molecules. Its unique chemical structure allows it to be a versatile building block in the development of new therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, 6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE is used as a reagent for the preparation of various organic compounds. Its sulfonyl chloride group can participate in a range of reactions, such as nucleophilic substitution and elimination reactions, making it a valuable tool for the synthesis of complex organic molecules.
Used in Benzoylthiophene Synthesis:
6-CHLOROIMIDAZO[2,1-B][1,3]THIAZOLE-5-SULFONYL CHLORIDE is used as a key intermediate in the synthesis of benzoylthiophenes, which are known to be allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor. This application highlights the compound's importance in the development of drugs targeting the adenosine receptor, which has potential therapeutic applications in various conditions, including neurodegenerative diseases and cardiovascular disorders.

InChI:InChI=1/C5H2Cl2N2O2S2/c6-3-4(13(7,10)11)9-1-2-12-5(9)8-3/h1-2H

Upstream product

• 23576-81-0 6-chloroimidazo[2,1-b]thiazole 

Downstream Products

• 1190482-07-5 6-chloro-N-(1-oxo-2,3-dihydro-1H-inden-4-yl)imidazo[2,1-b][1,3]thiazole-5-sulfonamide 
• 112582-89-5 6-chloro-imidazo[2,1-b]thiazole-5-sulfonic acid amide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-IMIDAZO [2,1-B] THIAZOLE-5-SULFONYL HALIDE

The present invention is related to the a new process for the preparation of 6-substituted-imidazo [2,1 -b] thiazole-5-sulfonyl halides of formula (I), comprising gradually adding a compound of formula (Il), into a heated solution of R1SO3H where R1 represents F or Cl, and R2 represents H, F, Cl, Br, S, (C1C6)alkyl, (C1-C6)alkoκy or triftuoromethyl.