150047-85-1

Basic information

• Product Name: FMOC-GLU(OCHX)-OH
• Synonyms: FMoc-Glu(OcHx)-OH FMoc-L-glutaMic acid γ-cyclohexyl ester;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(cyclohexyloxy)-5-oxopentanoic acid;Fmoc-L-Glu(OcHex)-OH;Fmoc-L-glutamic acid 5-cyclohexyl ester;Fmoc-L-glutamic acid γ-cyclohexyl ester99%;N-Fmoc-L-glutamic acid 5-cyclohexyl ester;FMOC-GLU(OCHEX)-OH;FMOC-GLU(OCHX)-OH
• CAS NO: 150047-85-1
• Molecular Formula: C26H29NO6
• Molecular Weight: 451.51
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 150047-85-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /Solid
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: FMOC-GLU(OCHX)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLU(OCHX)-OH(150047-85-1)
• EPA Substance Registry System: FMOC-GLU(OCHX)-OH(150047-85-1)

Safety Data

• Hazardous Substances Data: 150047-85-1(Hazardous Substances Data)

Usage

Description

FMOC-GLU(OCHX)-OH, also known as N-(9-fluorenylmethoxycarbonyl)-L-glutamic acid (1-oxo-2-chloroethyl) ester, is a synthetic compound commonly utilized in the field of peptide chemistry. It is a protected amino acid derivative that plays a crucial role in the synthesis of various proteins and peptides. The presence of the 9-fluorenylmethoxycarbonyl (Fmoc) group provides protection to the α-amino group, while the 1-oxo-2-chloroethyl (OCHX) ester group protects the α-carboxyl group. These protective groups are essential for the stepwise synthesis of peptides and proteins.

Uses

FMOC-GLU(OCHX)-OH is used as an intermediate in the synthesis of specific proteins and peptides for various applications in the biotechnology and pharmaceutical industries. The compound is particularly useful in the synthesis of darpin pe59 and barnase proteins, which have potential applications in drug development and therapeutics.
Used in Biotechnology Industry:
FMOC-GLU(OCHX)-OH is used as a building block for the synthesis of darpin pe59, a protein derived from the immunoglobulin domain of the antibody. Darpin pe59 has potential applications in the development of targeted therapeutics, as it can be engineered to bind specifically to various molecular targets, such as receptors or enzymes, involved in disease processes.
Used in Pharmaceutical Industry:
FMOC-GLU(OCHX)-OH is also used in the synthesis of barnase proteins, which are ribonucleases derived from Bacillus amyloliquefaciens. Barnase proteins have potential applications in the development of RNA-based therapeutics, as they can selectively degrade specific RNA molecules, thereby modulating gene expression and protein synthesis. Additionally, barnase proteins can be used as a tool for protein engineering and the development of novel bioactive molecules with tailored properties.