150585-92-5Relevant articles and documents
Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: Design and synthesis of one-carbon bridge derivatives
Aso,Imai,Yukishige,Ootsu,Akimoto
, p. 1280 - 1287 (2007/10/03)
A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinemonoph