1514927-36-6

Basic information

• Product Name: (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate
• Synonyms: (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate
• CAS NO: 1514927-36-6
• Molecular Weight: 405.453
• Mol File: 1514927-36-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate(1514927-36-6)
• EPA Substance Registry System: (-)-(S)-benzyl 2-((4-methoxyquinolin-8-yl)carbamoyl)pyrrolidine-1-carboxylate(1514927-36-6)

Safety Data

• Hazardous Substances Data: 1514927-36-6(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 147-85-3 L-proline 
• 6942-98-9 5-chloro-8-nitroquinoline 
• 1635-61-6 5-chloro-2-nitroaniline 
• 36020-53-8 6-methoxy-8-nitroquinoline 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 30465-68-0 5-methoxy-8-aminoquinoline 

Downstream Products

• 1514927-37-7 (-)-(1S,5R)-benzyl-6-(4-methoxyquinolin-8-yl)-7-oxo-2,6-diazabicyclo[3.2.0]heptane-2-carboxylate 
• 145574-16-9 benzyl (1S,5R)-7-oxo-2,6-diazabicyclo<3.2.0>heptane-2-carboxylate 

Relevant articles and documents

Regio- and stereospecific synthesis of C-3 functionalized proline derivatives by palladium catalyzed directed C(sp3)-H Arylation

Functionalization of C(sp3)-H bonds at the unactivated 3-position of proline derivatives has been achieved using aryl iodides and palladium catalysis. This directly affords cis-2,3-disubstituted pyrrolidines as single stereoisomers. 3-Arylation

Cis-fused ring-containing β-lactam the synthetic method of the compound of

The invention discloses a synthetic method of a beta-lactam compound with a cis condensed ring. Substituted or un-substituted pyrrole-2-formic acid, or substituted or un-substituted pyridine-2-formic acid or substituted or un-substituted indole-2-formic acid is used as a starting material, Pd(II) is adopted as a catalyst, and AgOAc or Ag2CO3 is used as an oxidant; a sp3C-H bond at a beta site of an amide substrate 2 (for example Scheme4) is activated through palladium catalysis; a key step of forming a C-N bond in a molecule to successfully construct a beta-lactam framework with the cis condensed ring is generated. According to the synthetic method disclosed by the invention, materials are simple and easily available, the price is cheap, the experiment operation is simple, the route is short and the yield is high; the synthetic method has very high atom economy, a little waste, environment friendliness, a wide scope of application of the substrate and good universality, and can be used for efficiently obtaining the beta-lactam compound with optical activity kept in a chiral manner.