15206-52-7

Basic information

• Product Name: 2-(dimethylamino)-3-methylbutanoic acid
• Synonyms: 2-(dimethylamino)-3-methylbutanoic acid
• CAS NO: 15206-52-7
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 15206-52-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(dimethylamino)-3-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(dimethylamino)-3-methylbutanoic acid(15206-52-7)
• EPA Substance Registry System: 2-(dimethylamino)-3-methylbutanoic acid(15206-52-7)

Safety Data

• Hazardous Substances Data: 15206-52-7(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 516-06-3 D,L-valine 
• 10323-40-7 2-bromoisovaleric acid 
• 124-40-3 dimethyl amine 
• 72-18-4 L-valine 
• 1494680-69-1 ohmyungsamycin B 

Downstream Products

• 138406-49-2 methyl (S)-(+)-mandelate ester of N,N-dimethyl-DL-valine 

Relevant articles and documents

Ohmyungsamycins A and B: Cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island

Ohmyungsamycins A and B (1 and 2), which are new cyclic peptides, were isolated from a marine bacterial strain belonging to the Streptomyces genus collected from a sand beach on Jeju, a volcanic island in the Republic of Korea. Based on the interpretation of the NMR, UV, and IR spectroscopic and MS data, the planar structures of 1 and 2 were elucidated as cyclic depsipeptides bearing unusual amino acid units, including N-methyl-4-methoxytrytophan, β-hydroxyphenylalanine, and N,N-dimethylvaline. The absolute configurations of the α-carbons of the amino acid residues were determined using the advanced Marfey's method. The configurations of the additional stereogenic centers at the β-carbons of the threonine, N-methylthreonine, and β-hydroxyphenylalanine units were assigned by GITC (2,3,4,6-tetra-O-acetyl- β-d-glucopyranosyl isothiocyanate) derivatization and the modified Mosher's method. We have developed a new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline. Our first successful establishment of the absolute configuration of N,N-dimethylvaline using PGME will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups. Ohmyungsamycins A and B showed significant inhibitory activities against diverse cancer cells as well as antibacterial effects.

RETROVIRAL PROTEASE INHIBITING COMPOUNDS

None

Studies of the N-oxides of N,N-dialkylamino acids. I. The synthesis of N,N-dimethyl neutral amino acids and corresponding N-oxides.

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