1521-45-5Relevant articles and documents
BIOCATALYTIC PREPARATION OF BICYCLOHEPTANE DERIVATIVES
Klempier, Norbert,Geymayer, Paul,Stadler, Peter,Faber, Kurt,Griengl, Herfried
, p. 111 - 118 (2007/10/02)
Bicyclohept-2-en-6-ols, central building blocks for the synthesis of chiral cyclobutane and -pentane systems, were prepared with up to >99percent e.e. by lipase catalysed resolution of their acetates, butyrates, or isobutyrates.Substituents at C-7 vicinal to the reaction site reduced both enantioselectivity and reaction rate, whereas variation of the acid moiety showed a smaller influence.Among the lipases tested, those from Pseudomonas sp. were shown to be superior to those from Candida cylindracea, Mucor sp. and porcine pancreas.