152434-79-2

Basic information

• Product Name: 1-(benzyloxy)-2,5-difluorobenzene
• Synonyms: 1-(benzyloxy)-2,5-difluorobenzene
• CAS NO: 152434-79-2
• Molecular Weight: 220.219
• Mol File: 152434-79-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(benzyloxy)-2,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzyloxy)-2,5-difluorobenzene(152434-79-2)
• EPA Substance Registry System: 1-(benzyloxy)-2,5-difluorobenzene(152434-79-2)

Safety Data

• Hazardous Substances Data: 152434-79-2(Hazardous Substances Data)

Usage

Appearance

White solid

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Building block in the synthesis of pharmaceuticals and agrochemicals
b. Intermediate in the production of fine chemicals

Stability and activity

Enhanced by the benzyloxy group in the molecule

Value

Valuable in the field of medicinal chemistry

Applications

Potential applications in the pharmaceutical and chemical industries

Upstream product

• 2713-31-7 2,5-difluorophenol 
• 100-39-0 benzyl bromide 

Downstream Products

• 152434-84-9 N-formyl-3,4-bis(benzyloxy)-2,5-difluorophenethanolamine 
• 152434-85-0 N-methyl-3,4-bis(benzyloxy)-2,5-difluorophenethanolamine 
• 152434-83-8 2,3-bis(benzyloxy)-2,5-difluorophenatholamine 
• 152434-82-7 3,4-bis(benzyloxy)-2,5-difluorobenzaldehyde 
• 152434-81-6 1,2-bis(benzyloxy)-3,6-difluorobenzene 
• 152434-80-5 2-(benzyloxy)-3,6-difluorophenol 

Relevant articles and documents

Syntheses of 2,5- and 2,6-Difluoronorepinephrine, 2,5-Difluoroepinephrine, and 2,6-Difluorophenylephrine: Effect of Disubstitution with Fluorine on Adrenergic Activity

Synthetic routes to difluorinated analogs of the adrenergic agonists, norepinephrine (NE), epinephrine (E), and phenylephrine (PE) have been developed.The syntheses were based on elaboration of the ethanolamine side chains from the appropriately polyfunctionalized benzaldehydes.The benzaldehydes were prepared from precursor difluorinated benzenes by sequential regioselective lithiations and reaction with electrophiles to introduce hydroxyl and carboxaldehyde functionalities.Binding and functional assay data demonstrate that the 2,6-difluorinated analogs are relatively inactive at both α- and β-adrenergic receptors.These results are consistent with earlier observations that 2-fluoro substitution of adrenergic agonists decreases α-adrenergic activity whereas 6-fluoro substitution decreases β-adrenergic activity.