152460-09-8

Basic information

• Product Name: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine
• Synonyms: N-(2-METHYL-5-NITROPHENYL)-4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;2-primidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl);2-pyrimidinamine,N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl);N-(2-methyl-5-nitrophenyl)-4-(3-pyridinyl)-2-pydimidineamine;(2-methyl-5-nitrophenyl)-(4-(pyridin-3-yl)pyrimidin-2-yl)amine;N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyriMid;2-Methyl-5-nitro-N-[4-(pyridin-3-yl)pyriMidin-2-yl]benzenaMine;IMatinib Related CoMpound
• CAS NO: 152460-09-8
• Molecular Formula: C₁₆H₁₃N₅O₂
• Molecular Weight: 307.31
• EINECS: 1806241-263-5
• Product Categories: Imatinib;Aromatics;Bases & Related Reagents;Nucleotides;Intermediate of Imatinib
• Mol File: 152460-09-8.mol
• Article Data: 53

Chemical Properties

• Melting Point: 188-193°C
• Boiling Point: 546.609 °C at 760 mmHg
• Flash Point: 284.379 °C
• Appearance: Yellow/Solid
• Density: 1.344 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.68±0.12(Predicted)
• CAS DataBase Reference: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(152460-09-8)
• EPA Substance Registry System: N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine(152460-09-8)

Safety Data

• Hazardous Substances Data: 152460-09-8(Hazardous Substances Data)

Usage

Description

N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine, with the CAS number 152460-09-8, is a chemical compound that is characterized as a yellow solid. It is primarily utilized in the field of organic synthesis due to its unique chemical properties and structure.

Uses

Used in Organic Synthesis:
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine is used as a synthetic building block for the creation of various complex organic molecules. Its application in this field is due to its ability to participate in a range of chemical reactions, such as condensation, substitution, and addition reactions, which are crucial for the synthesis of target compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine is used as a key intermediate in the development of new drugs. Its unique chemical structure allows it to be a potential candidate for the design and synthesis of novel therapeutic agents, particularly those targeting specific biological receptors or enzymes.
Used in Chemical Research:
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine is also employed in chemical research as a model compound to study various reaction mechanisms and to understand the reactivity of different functional groups. This knowledge can be applied to develop new synthetic strategies and improve existing ones.
Used in Material Science:
In the field of material science, N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine can be used as a component in the development of new materials with specific properties, such as optical, electronic, or magnetic characteristics. Its incorporation into these materials can lead to the creation of advanced materials with potential applications in various industries.

Upstream product

• 55314-16-4 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 152460-08-7 1-(2-methyl-5-nitrophenyl)guanidine nitrate 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 350-03-8 methyl-3-pyridylketone 
• 99-55-8 2-methyl-5-nitroaniline 
• 483324-01-2 2-chloro-4-(pyridin-3-yl)pyrimidine 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 66521-66-2 4-pyridin-3-ylpyrimidin-2-ylamine 
• 39883-42-6 β-oxo-3-pyridinepropanal sodium salt 
• 152460-07-6 1-(2-methyl-5-nitrophenyl)guanidine 
• 1026747-41-0 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)pyrimidine-5-carboxylic acid 
• 152460-08-7 (2-methyl-5-nitrophenyl)guanidine nitrate 
• 1207534-99-3 N-(2-methyl-5-nitrophenyl)guanidinium hydrochloride 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 152460-10-1 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 152459-95-5 imatinib 
• 404844-11-7 4-(chloromethyl)-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]-amino}phenyl)benzamide 
• 152459-94-4 N-(4-methyl-3(4-(pyridine-3-yl)pyrimidin-2-ylamino)phenyl)benzamide 
• 1207619-86-0 N-(2-(methyl-d3)-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine 
• 220127-57-1 imatinib mesylate 
• 475587-16-7 4-chloro-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzenesulfonamide 
• 1349893-81-7 N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)biphenyl-4-sulfonamide 
• 1349893-82-8 N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)naphthalene-2-sulfonamide 
• 1349893-83-9 N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)quinoline-3-sulfonamide 
• 1346617-86-4 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine 
• 1450754-50-3 C₂₀H₁₉N₅O₃ 
• 1450754-51-4 C₂₇H₂₈N₈O₂ 
• 593281-60-8 N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperidin-1-ylmethyl)benzamide 

Relevant articles and documents

SUBSTITUTED ARYLUREA COMPOUNDS FOR INDUCING APOPTOSIS AND COMPOSITION FOR ANTICANCER COMPRISING THE SAME

The present invention relates to a substituted arylurea compound inducing apoptosis and an anticancer composition comprising the same. The present invention relates to a novel compound capable of preventing, treating and alleviating cancer diseases such as prostate cancer, breast cancer, lung cancer, colorectal cancer, and skin cancer by inhibiting apoptosis of cancer cells and inhibiting proliferation of cancer cells.

Synthesis method of imatinib and imatinib mesylate

The invention relates to a synthesis method of imatinib and imatinib mesylate. The method comprises the following steps: condensing 3-acetylpyridine and N,N-dimethylformamide dimethyl acetal which aretaken as initial raw materials to obtain 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one, then reacting with 2-methyl-5-nitrophenylguanidine nitrate to form a pyrimidine ring, performing nitro reductionto obtain N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine, amidating the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine and 4-(chloromethyl)benzoyl chloride, performing affinitysubstitution with 1-methylpiperazine to obtain imatinib, and salifying the imatinib and methanesulfonic acid. The products obtained by the method have the advantages of few impurities, simplicity in post-treatment, high total yield, greenness, environmental protection and safety, and is suitable for a production process for large-scale industrial production of imatinib mesylate.

N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity, and preparation method thereof

The invention discloses an N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity, and a preparation method thereof, and belongs to the technical field of medicine synthesis. The structural formula of the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with medicine activity is shown in the description. The invention also discloses a preparation method for the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative with anti-cancer activity. The N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine derivative prepared with the preparation method has good inhibition activity for lung carcinoma cells A549, and has a potential for becoming an anti-tumor medicine.