152684-20-3

Basic information

• Product Name: N-methyl-3-nitro-5-phenylpyridin-2-amine
• Synonyms: N-methyl-3-nitro-5-phenylpyridin-2-amine
• CAS NO: 152684-20-3
• Molecular Weight: 229.238
• Mol File: 152684-20-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-3-nitro-5-phenylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-3-nitro-5-phenylpyridin-2-amine(152684-20-3)
• EPA Substance Registry System: N-methyl-3-nitro-5-phenylpyridin-2-amine(152684-20-3)

Safety Data

• Hazardous Substances Data: 152684-20-3(Hazardous Substances Data)

Upstream product

• 4093-88-3 2-(methylamino)-3-nitropyridine 
• 152684-30-5 5-bromo-2-methoxy-3-nitropyridine 
• 84539-30-0 5-bromo-N-methylpyridin-2-amine 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 1072-97-5 5-bromo-2-pyridylamine 
• 152684-31-6 2-methoxy-3-nitro-5-phenylpyridine 
• 74-89-5 methylamine 
• 70232-59-6 5-bromo-N-methyl-3-nitropyridin-2-amine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 107351-86-0 N²-methyl-5-phenylpyridine-2,3-diamine 

Relevant articles and documents

Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles

The development of a reagent for the efficient synthesis of five- and six-membered azoles at room temperature is proposed. A variety of substituted 2-aminobenzimidazoles are synthesized in good to excellent yields. The ability to incorporate various protecting groups makes the imidoyl dichloride reagent amenable to a large number of syntheses. The reagent is applied to the total synthesis of the 2-aminobenzimidazole containing carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), from 2-chloro-3-nitropyridine in >60% yield in 6 steps.

Synthetic Routes to Nitroamino Precursors of the Food Carcinogen 2-Amino-1-methyl-6-phenyl-1H-imidazopyridine and its 3-Methyl Isomer via Pd(0)-Catalysed Arylation

The synthesis of the novel key intermediates 3-methylamino-2-nitro- and 2-methylamino-3-nitro-5-phenylpyridine, and some of their derivatives substituted in the benzene ring, from 5-bromonicotinic acid, 3-bromo-5-methoxypyridine, 2-chloro-3-nitropyridine, 2-amino-5-bromopyridine or 5-bromo-2-methoxypyridine is described.Palladium(0)-mediated arylation of bromopyridines with areneboronic acids was an essential step in the syntheses.