15274-43-8 Usage
Description
Dichlorobis(tributylphosphine)nickel(II) is a metal catalyst with the chemical formula NiCl2(PBu3)2. It is a nickel-based compound that features two tributylphosphine ligands and two chloride ions. This catalyst is known for its ability to facilitate various chemical reactions, making it a valuable tool in the field of organic synthesis.
Uses
1. Used in Organic Synthesis:
Dichlorobis(tributylphosphine)nickel(II) is used as a catalyst for various coupling reactions, such as Wenkert arylations, regioselective [2+2+2] cycloadditions, and polymerization reactions. Its application in these reactions is due to its ability to promote the formation of new carbon-carbon or carbon-heteroatom bonds, leading to the synthesis of complex organic molecules.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, Dichlorobis(tributylphosphine)nickel(II) is used as a catalyst for the synthesis of complex drug molecules. Its ability to facilitate coupling reactions allows for the efficient production of target compounds, which can be further developed into potential drug candidates.
3. Used in Material Science:
Dichlorobis(tributylphosphine)nickel(II) is also utilized in the field of material science, particularly in the synthesis of advanced polymers and materials with specific properties. Its catalytic activity enables the production of materials with tailored characteristics, such as improved mechanical strength, thermal stability, or electrical conductivity.
4. Used in Environmental Applications:
In environmental applications, Dichlorobis(tributylphosphine)nickel(II) can be employed as a catalyst for the degradation of pollutants or the synthesis of environmentally friendly materials. Its ability to promote chemical reactions can be harnessed to develop processes that help reduce the environmental impact of various industrial activities.
5. Used in Research and Development:
Dichlorobis(tributylphosphine)nickel(II) is a valuable catalyst in research and development laboratories, where it is used to explore new reaction pathways and develop innovative synthetic methods. Its versatility and reactivity make it an essential tool for chemists working on the design and synthesis of novel compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 15274-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,7 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 15274-43:
(7*1)+(6*5)+(5*2)+(4*7)+(3*4)+(2*4)+(1*3)=98
98 % 10 = 8
So 15274-43-8 is a valid CAS Registry Number.
InChI:InChI=1/2C12H27P.2ClH.Ni/c2*1-4-7-10-13(11-8-5-2)12-9-6-3;;;/h2*4-12H2,1-3H3;2*1H;/q;;;;+2
15274-43-8Relevant articles and documents
Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate
Boyer, Serge H.,De Vries, André H. M.,Dielemans, J. A. Hubertus,Gnahn, Matthias,Gonzalez-De-Castro, Angela,Hecker, Scott J.,Lefort, Laurent,Sch?rghuber, Julia,Steinhofer, Stefan,Zhu, Zuolin
supporting information, (2021/10/01)
We report the scalable, high-yielding, and highly selective synthesis of the β-lactamase inhibitor QPX7728 featuring two key synthetic steps: nickel-catalyzed boron insertion of benzofuran 1 followed by enantioselective cyclopropanation of the resulting cyclic vinylboronate 2. The identification of the key reagents (catalyst and chiral auxiliary) for both steps relied on the use of high-throughput experimentation. Further optimization allowed for the cost-effective and scalable production of QPX7728.
Synthesis and fluxional behavior of [bis(trialkylphosphine)nickelio]anthracene (alkyl = Et, Bu)
Stanger, Amnon,Vollhardt, K. Peter C.
, p. 317 - 320 (2008/10/08)
The title compounds were prepared from the respective (R3P)2NiCl2 complexes and magnesium-anthracene-(THF)3 (or anthracene in the presence of Mg or C8K). The assignment of the anthracene proton NMR si
