153127-42-5

Basic information

• Product Name: CYCLOCURCUMIN(P)
• Synonyms: CYCLOCURCUMIN(P)
• CAS NO: 153127-42-5
• Molecular Formula: C21H20O6
• Molecular Weight: 368.383
• Mol File: 153127-42-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 571.9±50.0 °C(Predicted)
• Appearance: Yellow Powder
• Density: 1.352±0.06 g/cm3(Predicted)
• PKA: 9.66±0.35(Predicted)
• CAS DataBase Reference: CYCLOCURCUMIN(P)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOCURCUMIN(P)(153127-42-5)
• EPA Substance Registry System: CYCLOCURCUMIN(P)(153127-42-5)

Safety Data

• Hazardous Substances Data: 153127-42-5(Hazardous Substances Data)

Usage

General Description

Cyclocurcumin(P) is a synthetic analog of the naturally occurring compound curcumin, which is found in the spice turmeric. It has been studied for its potential anti-inflammatory and anti-cancer properties. Cyclocurcumin(P) has been shown to have stronger antioxidant and anti-inflammatory activity than curcumin, making it a promising candidate for the development of new therapeutic agents for conditions such as cancer, arthritis, and inflammatory diseases. Research also suggests that Cyclocurcumin(P) may have neuroprotective effects and could be beneficial for the treatment of neurodegenerative diseases. Its potent biological activities make it a valuable compound for further research and potential development into pharmaceuticals.

Upstream product

• 98885-93-9 curcumin 
• 458-37-7 curcumin 

Relevant articles and documents

Nematocidal activity of turmeric: Synergistic action of curuminoids

A new curcuminoid, cyclocurcumin (IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin (I), demethoxycurcumin (II) and bisdemethoxycurcumin (III). The structur

The effectiveness of natural diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, ultrastructural alterations and molecular modeling studies

Curcumin (CUR) is the major constituent of the rhizomes of Curcuma longa and has been widely investigated for its chemotherapeutic properties. The well-known activity of CUR against Leishmania sp., Trypanosoma brucei and Plasmodium falciparum led us to investigate its activity against Trypanosoma cruzi. In this work, we tested the cytotoxic effects of CUR and other natural curcuminoids on different forms of T. cruzi, as well as the ultrastructural changes induced in epimastigote form of the parasite. CUR was verified as the curcuminoid with more significant trypanocidal properties (IC50 10.13 μM on epimastigotes). Demethoxycurcumin (DMC) was equipotent to CUR (IC50 11.07 μM), but bisdemethoxycurcumin (BDMC) was less active (IC50 45.33 μM) and cyclocurcumin (CC) was inactive. In the experiment with infected murine peritoneal macrophages all diarylheptanoids were more active than the control in the inhibition of the trypomastigotes release. The electron microscopy images showed ultrastructural changes associated with the cytoskeleton of the parasite, indicating tubulin as possible target of CUR in T. cruzi. The results obtained by flow cytometry analysis of DNA content of the parasites treated with natural curcuminoids suggested a mechanism of action on microtubules related to the paclitaxel's mode of action. To better understand the mechanism of action highlighted by electron microscopy and flow cytometry experiments we performed the molecular docking of natural curcuminoids on tubulin of T. cruzi in a homology model and the results obtained showed that the observed interactions are in accordance with the IC50 values found, since there CUR and DMC perform similar interactions at the binding site on tubulin while BDMC do not realize a hydrogen bond with Lys163 residue due to the absence of methoxyl groups. These results indicate that trypanocidal properties of CUR may be related to the cytoskeletal alterations.