153379-66-9

Basic information

• Product Name: (1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate
• Synonyms: (1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate
• CAS NO: 153379-66-9
• Molecular Weight: 332.4
• Mol File: 153379-66-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate(153379-66-9)
• EPA Substance Registry System: (1S,6S,8aS)-6-(benzyloxycarbonylamino)octahydroindolizin-1-yl acetate(153379-66-9)

Safety Data

• Hazardous Substances Data: 153379-66-9(Hazardous Substances Data)

Upstream product

• 82611-65-2 N-benzyloxycarbonyl-S-phenyl-L-cysteine 
• 153277-27-1 (2S,3S)-2-[(E)-(S)-3-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-but-1-enyl]-3-methoxymethoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 153277-22-6 (R)-benzyl (1-hydroxy-3-(phenylthio)propan-2-yl)carbamate 
• 194924-98-6 (2R,3S)-3-Methoxymethoxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 153277-26-0 (2S,3S,1'S,2'R,3'R)-1-(tert-Butoxycarbonyl)-2-<3'-benzyloxycarbonylamine-4'-(tert-butyldimethylsilyloxy)-1'-hydroxy-2'-phenylsulfonylbutyl>-3-(methoxymethoxy)pyrrolidine 
• 153277-28-2 (2S,3S,3'S)-2-<4'-(tert-Butyldimethylsilyloxy)-3'-(benzyloxycarbonylamino)butyl>-1-(tert-butoxycarbonyl)-3-(methoxymethoxy)pyrrolidine 
• 153277-32-8 (2S,3S)-2-((S)-3-Benzyloxycarbonylamino-4-methanesulfonyloxy-butyl)-3-methoxymethoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 153277-31-7 (2S,3S)-2-((S)-3-Benzyloxycarbonylamino-4-hydroxy-butyl)-3-methoxymethoxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 153277-21-5 (R)-2-Benzyloxycarbonylamino-1-(tert-butyldimethylsilyloxy)-3-phenylsulfonylpropane 
• 153277-34-0 (R)-2-Benzyloxycarbonylamino-1-(tert-butyldimethylsilyloxy)-3-phenylthiopropane 
• 132249-34-4 Methyl (S)-2-benzyloxycarbonylamino-3-methylsulfonyloxypropanoate 
• 153277-33-9 N-benzyloxycarbonyl-S-phenyl-L-cysteine methyl ester 
• 153277-29-3 ((1S,6S,8aS)-1-Methoxymethoxy-octahydro-indolizin-6-yl)-carbamic acid benzyl ester 
• 194924-97-5 Methyl (2R,3S)-1-(tert-butoxycarbonyl)-3-(methoxymethoxy)pyrrolidine-2-carboxylate 

Downstream Products

• 20084-93-9 (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizidine 
• 20084-93-9 (-)-slaframine 

Relevant articles and documents

Highly Enantioselective Approach to Indolizidines: Preparation of (+)-(1S,8aS)-1-Hydroxyindolizidine and (-)-Slaframine

A highly stereoselective approach to (-)-slaframine and its probable biosynthetic precursor (+)-(1S,8aS)-1-hydroxyindolizidine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether.

A total synthesis of (-)-slaframine from (+)-cis-(2R,3S)-3-hydroxyproline

A total synthesis of the naturally occurring indolizidine (-)-Slaframine 4 has been achieved, starting from the cis-3-hydroxyproline derivative 1, in which a key step is a Julia olefination reaction using the dianion derived from the β-aminosulfone 5.