153646-82-3

Basic information

• Product Name: 2-Pyridinecarboxaldehyde,6-ethyl-(9CI)
• Synonyms: 2-Pyridinecarboxaldehyde,6-ethyl-(9CI);6-Ethylpicolinaldehyde
• CAS NO: 153646-82-3
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.16316
• Product Categories: PYRIDINE
• Mol File: 153646-82-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 205.4±28.0 °C(Predicted)
• Appearance: /
• Density: 1.063±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.93±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxaldehyde,6-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxaldehyde,6-ethyl-(9CI)(153646-82-3)
• EPA Substance Registry System: 2-Pyridinecarboxaldehyde,6-ethyl-(9CI)(153646-82-3)

Safety Data

• Hazardous Substances Data: 153646-82-3(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxaldehyde,6-ethyl-(9CI) is a chemical compound with the molecular formula C9H9NO. It is also known by its CAS number 6020-29-1. 2-Pyridinecarboxaldehyde,6-ethyl-(9CI) is an aldehyde derivative of pyridine and contains an ethyl group at the 6th position. It is commonly used as a building block in the synthesis of various organic compounds and pharmaceuticals. This chemical may also have potential applications in the field of agrochemicals and materials science. Furthermore, it is important to handle this compound with proper care, as it may have hazardous properties and should be used in a controlled laboratory setting.

Upstream product

• 163658-33-1 6-ethyl-2-(hydroxymethyl)pyridine 
• 688-99-3 5-hexen-3-ol 
• 202817-14-9 ethyl 5-(2-hydroxybutyl)-2-isoxazoline-3-carboxylate 
• 134370-37-9 Ethyl 5-(2-Oxobutyl)-2-isoxazoline-3-carboxylate 
• 41337-78-4 Ethyl 6-Ethyl-2-pyridinecarboxylate 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 142-25-6 N,N',N'-trimethylenediamine 
• 74-88-4 methyl iodide 

Downstream Products

• 162739-97-1 N-methyl-N-<(6-ethyl-2-pyridinyl)methyl>amine 
• 153646-83-4 6-isopropyl-2-pyridinecarboxaldehyde 
• 1298133-30-8 (R)-N-(6-ethylpyridyl-2-methyl)-7-di-(3,5-di-tert-butylphenyl)phosphino-7'-amino-1,1'-spiro-dihydro-indene 

Relevant articles and documents

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy

The structure-activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately potent and orally bioavailable inhibitor A-80987, systematic investigation of peripheral (P3 and P2') heterocyclic groups designed to decrease the rate of hepatic metabolism provided analogues with improved pharmacokinetic properties after oral dosing in rats. Replacement of pyridyl groups with thiazoles provided increased chemical stability toward oxidation while maintaining sufficient aqueous solubility for oral absorption. Optimization of hydrophobic interactions with the HIV protease active site produced ritonavir, with excellent in vitro potency (EC50 = 0.02 μM) and high and sustained plasma concentrations after oral administration in four species. Details of the discovery and preclinical development of ritonavir are described.