15384-39-1

Basic information

• Product Name: (3-Methoxy-phenyl)-hydrazine
• Synonyms: (3-Methoxy-phenyl)-hydrazine;m-Methoxyphenylhydrazine;Hydrazine, (3-methoxyphenyl)-
• CAS NO: 15384-39-1
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.17
• Product Categories: Benzene series
• Mol File: 15384-39-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 59-60 °C
• Boiling Point: 275℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.150
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.41±0.10(Predicted)
• CAS DataBase Reference: (3-Methoxy-phenyl)-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Methoxy-phenyl)-hydrazine(15384-39-1)
• EPA Substance Registry System: (3-Methoxy-phenyl)-hydrazine(15384-39-1)

Safety Data

• Hazardous Substances Data: 15384-39-1(Hazardous Substances Data)

Usage

Description

(3-Methoxy-phenyl)-hydrazine, with the chemical formula C7H10N2O, is a colorless to yellow liquid that exhibits a slight amine odor. This chemical compound serves as a versatile intermediate in the synthesis of various products, including pharmaceuticals, agrochemicals, dyes, and pigments.

Uses

Used in Pharmaceutical Industry:
(3-Methoxy-phenyl)-hydrazine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and improve the efficacy of existing ones.
Used in Agrochemical Industry:
In the agrochemical sector, (3-Methoxy-phenyl)-hydrazine is utilized as an intermediate in the production of agrochemicals, helping to create compounds that protect crops and enhance agricultural productivity.
Used in Dye and Pigment Industry:
(3-Methoxy-phenyl)-hydrazine is employed as an intermediate for the preparation of dyes and pigments, contributing to the creation of a wide range of colors used in various industries, such as textiles, plastics, and printing.
Safety Precautions:

Upstream product

• 536-90-3 m-Anisidine 
• 39232-91-2 m-methoxyphenylhydrazine hydrochloride 
• 3899-92-1 3-methoxyphenyl 4-methylbenzenesulfonate 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 766-85-8 3-methoxy-1-iodobenzene 

Downstream Products

• 68962-14-1 1,2,3,4-tetrahydro-5-methoxycarbazole 
• 3382-43-2 7-methoxy-2,3,4,9-tetrahydro-1H-carbazole 
• 372093-71-5 6-methoxy-3-methyl-2-phenylindole 
• 109596-28-3 1-(3-methoxy-phenylhydrazono)-1,2,3,4-tetrahydro-quinolizinylium; iodide 
• 109648-93-3 1-(3-methoxy-phenylhydrazono)-1,2,3,4-tetrahydro-quinolizinylium; bromide 
• 58176-56-0 6-methoxy-2,3-dimethyl-1H-indole 
• 97881-50-0 (1-Phenylmercapto-aceton)-3-methoxy-phenylhydrazon 
• 93896-38-9 (1-Ethoxycarbonylmethylmercapto-aceton)-3-methoxy-phenylhydrazon 
• 93988-08-0 Phenylmercaptoacetaldehyd-(3-methoxy-phenylhydrazon) 
• 112252-47-8 Propionic acid N'-(3-methoxy-phenyl)-hydrazide 
• 103973-43-9 deoxybenzoin m-methoxyphenylhydrazone 
• 113575-81-8 C₁₂H₁₇N₃OS 
• 141502-64-9 C₁₂H₁₇N₃OS 
• 97456-64-9 3-methoxyphenylhydrazone of 2,3-piperidinedione 

Relevant articles and documents

Synthesis and antiinflammatory activity of 2,3-bis(p-methoxyphenyl)indole and related compounds.

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Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid

N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.

Synthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbocylic acid chlorides with tryptamine derivatives afforded substituted 1-aryl-N-[2-(1H-indol-3-yl) ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. At heating these compounds in toluene in the presence of POCl3 and P2O5 Bischler-Napieralski cyclization occurs giving 1-(1-aryl-5-methyl-1H-1,2,3- triazol-4-yl)-4,9-dihydro-3H-β-carbolines that can be transformed into β-carboline and tetrahydro-β-carboline derivatives.