153901-93-0

Basic information

• Product Name: 5-(2-Methoxy-pyridin-4-ylmethyl)-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylamino]-1H-pyrimidin-4-one
• Synonyms: 5-(2-Methoxy-pyridin-4-ylmethyl)-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylamino]-1H-pyrimidin-4-one
• CAS NO: 153901-93-0
• Molecular Weight: 463.58
• Mol File: 153901-93-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(2-Methoxy-pyridin-4-ylmethyl)-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylamino]-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-Methoxy-pyridin-4-ylmethyl)-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylamino]-1H-pyrimidin-4-one(153901-93-0)
• EPA Substance Registry System: 5-(2-Methoxy-pyridin-4-ylmethyl)-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propylamino]-1H-pyrimidin-4-one(153901-93-0)

Safety Data

• Hazardous Substances Data: 153901-93-0(Hazardous Substances Data)

Upstream product

• 72716-88-2 ethyl 2-formyl-3-(2-methoxy-pyridin-4-yl)propionate 
• 92838-85-2 Ethyl β-(2-methoxy-4-pyridyl)propionate 
• 153902-00-2 (E)-3-(2-Methoxy-pyridin-4-yl)-acrylic acid ethyl ester 
• 72716-87-1 2-methoxypyridine-4-carboxaldehyde 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 72716-89-3 2-nitroamino-5-(2-methoxy-pyridin-4-yl)methyl-4-pyrimidone 

Relevant articles and documents

Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK and F 93574) and related compounds

The synthesis and biological activity of some novel 2-amino-4-pyrimidone derivatives is described.Side-chains associated with H2 antagonist activity are attached through the 2-amino group, whilst a range of 2-hydroxypyridine containing moieties are substituted at the 5-position of the pyrimidone ring.Good H2-receptor histamine antagonist activity is observed with all the series and the majority of the compounds are selective for the H2-receptor.High aqueous solubility and iv potency coupled with an extended duration of biological activity in animal models ledto compound 16c, 2--5-(2-hydroxypyrid-4-ylmethyl)-4-pyrimidone (donetidine, SK and F 93574) being selected for clinical investigation as a potential parenterally administered therapeutic agent.H2-receptor antagonists / 2-amino-4-pyrimidones (isocytosines / imidazoles / thiazoles / pyridines / furans / 2-guanidinothiazoles / donetidine (SK and F 93574)