153974-48-2Relevant articles and documents
Palladium-Catalyzed Carbonylative Cyclization of o-Allylbenzyl Halides To Produce Benzo-Annulated Enol Lactones and/or Bicyclohept-3-en-6-ones. An Efficient Route to U-68,215
Wu, Guangzhong,Shimoyama, Izumi,Negishi, Ei-ichi
, p. 6506 - 6507 (1991)
Treatment of o-allylbenzyl halides with CO in the presence of 1.5-2.0 equiv of a base, such as NEt3, and a catalytic amount of a palladium complex, such as Cl2Pd(PPh3)2, provides a 2,3,3a,4-tetrahydro-2-oxonaphthylfurans and/or cyclobutanone derivatives tentatively identified as 2,2a,7,7a-tetrahydro-1H-cyclobutinden-2-ones.
METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG
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Paragraph 90-91, (2014/06/24)
The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.
Palladium-catalyzed carbonylative cyclization via trapping of acylpalladium derivatives with internal enolates. Its scope and factors affecting the C-to-O ratio
Negishi, El-Ichi,Coperet, Christophe,Sugihara, Takumichi,Shimoyama, Izumi,Zhang, Yantao,Wu, Guangzhong,Tour, James M.
, p. 425 - 436 (2007/10/02)
The Pd-catalyzed carbonylative cyclization reaction involving ω-acyl-substituted acylpalladium derivatives can proceed via intramolecular trapping with either C- or O-enolates; the preferential formation of either 5- or 6-membered rings dictates the C-to-
