154064-09-2

Basic information

• Product Name: [2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester
• CAS NO: 154064-09-2
• Molecular Weight: 518.572
• Mol File: 154064-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester(154064-09-2)
• EPA Substance Registry System: [2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester(154064-09-2)

Safety Data

• Hazardous Substances Data: 154064-09-2(Hazardous Substances Data)

Upstream product

• 51012-65-8 2-bromo-1-o-tolylethanone 
• 152665-87-7 1,3-Dihydro-5-(pyridin-4-yl)-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one 
• 280568-15-2 {Benzotriazol-1-yl-[2-(pyridine-4-carbonyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 124676-19-3 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine 
• 91973-39-6 (2-Aminophenyl)-(pyridin-4-yl)methanone 

Relevant articles and documents

Synthesis and biological activity of 5-heteroaryl benzodiazepines: Analogues of YM022

A novel series of analogues of the potent gastrin/CCK-B receptor antagonist YM022 have been prepared which incorporate 5- and 6-membered heteroaromatic rings in the benzodiazepine 5-position. The 5-(2-pyridyl) derivatives in particular retained good in vitro and in vivo potency and one such compound 9i was shown to inhibit acid secretion after oral dosing in dogs. Improved bioavailability for 9i over the 5-phenyl analogue, 9h was demonstrated in rats.