154130-99-1

Basic information

• Product Name: 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
• Synonyms: 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE;PD 144418 OXALATE
• CAS NO: 154130-99-1
• Molecular Formula: C20H24N2O5
• Molecular Weight: 282.38
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals
• Mol File: 154130-99-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Desiccate at RT
• Solubility: <18.62mg/ml in DMSO
• CAS DataBase Reference: 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE(154130-99-1)
• EPA Substance Registry System: 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE(154130-99-1)

Safety Data

• Hazardous Substances Data: 154130-99-1(Hazardous Substances Data)

Usage

Description

1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE is a complex organic compound characterized by its unique molecular structure. It is a derivative of pyridine with an oxalate group and an isoxazolyl moiety, which contributes to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE is used as a high affinity, selective σ1 ligand for its interaction with σ1 receptors. This property makes it valuable in the development of drugs targeting specific receptors, potentially leading to more effective treatments with fewer side effects.
Used in Neuropharmacology Research:
In the field of neuropharmacology, 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE is used as a research tool to study the effects of σ1 ligands on neurological processes. Its high selectivity for σ1 receptors allows researchers to investigate the role of these receptors in various conditions and develop targeted therapies.
Used in Preclinical Models:
1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE is used as a compound in preclinical models to evaluate its potential therapeutic effects and safety. In particular, it has been shown to antagonize mescaline-induced scratching in mice following intraperitoneal administration, which could be relevant for studying its effects on certain neurological disorders.
Note: The provided materials do not mention any uses for glycerol. The example given for gallotannin is for reference purposes only.

Biological Activity

High affinity, selective σ 1 ligand (K i values are 0.08 and 1377 nM for σ 1 and σ 2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration.