154194-69-1

Basic information

• Product Name: N-Acetyl--alanine N-Hydroxysuccinimide Ester
• Synonyms: N-Acetyl--alanine N-Hydroxysuccinimide Ester;N-[3-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-3-oxopropyl]acetaMide;(2,5-Dioxopyrrolidin-1-yl) 3-acetamidopropanoate
• CAS NO: 154194-69-1
• Molecular Formula: C9H12N2O5
• Molecular Weight: 228.20198
• Product Categories: Amino Acids & Derivatives;Heterocycles;Intermediates
• Mol File: 154194-69-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 82-84°C
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, DMSO, Ethyl Acetate, Methanol
• PKA: 15.55±0.46(Predicted)
• CAS DataBase Reference: N-Acetyl--alanine N-Hydroxysuccinimide Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl--alanine N-Hydroxysuccinimide Ester(154194-69-1)
• EPA Substance Registry System: N-Acetyl--alanine N-Hydroxysuccinimide Ester(154194-69-1)

Safety Data

• Hazardous Substances Data: 154194-69-1(Hazardous Substances Data)

Usage

Description

N-Acetyl--alanine N-Hydroxysuccinimide Ester is an organic compound that serves as an intermediate in the synthesis of various chemical compounds. It is a light yellow liquid with unique chemical properties that make it suitable for use in different applications across various industries.

Uses

Used in Pharmaceutical Industry:
N-Acetyl--alanine N-Hydroxysuccinimide Ester is used as an intermediate for the preparation of polyamide inducers, which play a crucial role in promoting cellular differentiation in HL-60 cells. This application is particularly relevant in the development of treatments for certain types of cancer, as it helps in the differentiation and maturation of cancerous cells, potentially leading to a reduction in tumor growth.
Used in Chemical Synthesis:
As a versatile intermediate, N-Acetyl--alanine N-Hydroxysuccinimide Ester is also used in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique chemical properties allow it to be a valuable building block in the creation of new molecules with specific functions and applications.
Used in Research and Development:
Due to its potential applications in various fields, N-Acetyl--alanine N-Hydroxysuccinimide Ester is also utilized in research and development laboratories. Scientists and researchers use this compound to explore new chemical reactions, develop novel synthetic routes, and create innovative products with improved properties and performance.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 3025-95-4 N-acetyl-β-alanine 

Relevant articles and documents

Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides

Pyrrole-imidazole (Py-Im) polyamides are a group of chemicals that are able to bind specifically to DNA sequences in vitro and in mammalian cells. Using a cell based reporter assay, we investigated the size and linker affects on the cellular permeability