154825-97-5

Basic information

• Product Name: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE
• Synonyms: methyl 2-(4-bromophenyl)-2-methylpropanoate;α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester;Benzeneacetic acid,4-broMo-a,a-diMethyl-, Methyl ester;Benzeneacetic acid, 4-bromo-α,α-dimethyl-, methyl ester;2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE;p-Bromo-alpha,alpha-Dimethylphenylacetic acid methyl ester;2-methyl-2-(p-bromophenyl)propionic acid methyl ester;P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster
• CAS NO: 154825-97-5
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.12372
• EINECS: 1308068-626-2
• Product Categories: Intermediates;Miscellaneous Reagents;Aromatics Compounds;Aromatics
• Mol File: 154825-97-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: Colourless oil
• Density: 1.337
• Vapor Pressure: 0.00209mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Refrigerator
• Water Solubility: 43mg/L at 20℃
• CAS DataBase Reference: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE(154825-97-5)
• EPA Substance Registry System: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE(154825-97-5)

Safety Data

• Hazardous Substances Data: 154825-97-5(Hazardous Substances Data)

Usage

Description

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE, with the CAS number 154825-97-5, is a colorless oil compound that is primarily utilized in the field of organic synthesis. It is known for its unique chemical properties, which make it a valuable component in the creation of various organic compounds.

Uses

Used in Organic Synthesis:
METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity allow it to be a versatile building block for the development of new molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE is used as a starting material for the development of new drugs. Its chemical properties make it suitable for the synthesis of various drug candidates, which can be further modified and optimized for specific therapeutic applications.
Used in Chemical Research:
METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE is also used in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its unique structure provides researchers with valuable insights into the reactivity of similar compounds and helps in the design of novel synthetic routes.
Used in Material Science:
In the field of material science, METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE can be used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C11H13BrO2/c1-11(2,10(13)14-3)8-4-6-9(12)7-5-8/h4-7H,1-3H3

Upstream product

• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 74-88-4 methyl iodide 
• 83636-46-8 methyl 2-(4-bromophenyl)propanoate 
• 1634-04-4 tert-butyl methyl ether 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 
• 67-56-1 methanol 
• 71-43-2 benzene 
• 589-87-7 1,4-bromoiodobenzene 
• 23426-63-3 2-bromo-2-methylpropionic acid methyl ester 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 154825-93-1 4-(4-Hydroxy-1-butynyl)-α,α-dimethylbenzeneacetic acid methyl ester 
• 444807-47-0 methyl 2-(4-cyanophenyl)-2-methylpropanoate 
• 154825-94-2 4-<4-(Methanesulfonyloxy)-1-butynyl>-α,α-dimethylbenzeneacetic acid methyl ester 
• 154825-95-3 4-<4-<4-(Hydroxydiphenylmethyl)-1-piperidinyl>-1-butynyl>-α,α-dimethylbenzeneacetic acid methyl ester 
• 154477-55-1 methyl 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoate 
• 83799-24-0 fexofenadine 
• 154825-96-4 fexofenadine methyl ester 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 
• 897935-07-8 5-[1-(4-bromophenyl)-1-methylethyl]-1H-1,2,4-triazol-3-amine 
• 32454-37-8 2,2-dimethyl-2-(4-bromophenyl)ethanol 
• 890839-10-8 methyl 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 
• 915084-42-3 2-(4-(benzyloxycarbonylamino)phenyl)-2-methylpropanoic acid methyl ester 
• 1021432-52-9 methyl 2-(4-cyclopropylphenyl)-2,2-dimethylacetate 
• 1075217-19-4 methyl 2-{4-[(7-amino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethynyl]phenyl}-2-methylpropanoate 

Relevant articles and documents

DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE

Provided herein are a dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B. Specifically, provided herein is a compound having Formula (I) or (Ia), or a stereisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B.

Dihydropyrimidine compound and uses of dihydropyrimidine compound in drugs

The present invention relates to a dihydropyrimidine compound and uses of the dihydropyrimidine compound as drugs, particularly as drugs for treatment and prevention of hepatitis B, particularly to acompound represented by a general formula (I) or (Ia) or an enantiomer, a diastereomer, a tautomer, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, wherein each variable is definedin the specification. The invention further relates to uses of the compound represented by a general formula (I) or (Ia) or the enantiomer, the diastereomer, the tautomer, the hydrate, the solvate orthe pharmaceutically acceptable salt thereof as drugs, especially as drugs for treatment and prevention of hepatitis B. The formulas (I) and (Ia) are defined in the specification.

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.