1551492-24-0Relevant articles and documents
In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase
Taha, Muhammad,Ismail, Nor Hadiani,Imran, Syahrul,Rahim, Fazal,Wadood, Abdul,Al Muqarrabun, Laode Muhammad Ramadhan,Khan, Khalid Mohammed,Ghufran, Mehreen,Ali, Muhammad
, p. 80 - 89 (2016)
Thymidine phosphorylase (TP) is up regulated in wide variety of solid tumors and therefore presents a remarkable target for drug discovery in cancer. A novel class of extremely potent TPase inhibitors based on benzopyrazine (1–28) has been developed and e
Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl) quinoxalines, a promising and potent new class of anticancer agents
Rodrigues, Felipe A.R.,Bomfim, Igor Da S.,Cavalcanti, Bruno C.,Pessoa, Claudia Do ó.,Wardell, James L.,Wardell, Solange M.S.V.,Pinheiro, Alessandra C.,Kaiser, Carlos Roland,Nogueira, Thais C.M.,Low, John N.,Gomes, Ligia R.,De Souza, Marcus V.N.
, p. 934 - 939 (2014/02/14)
A series of forty-seven quinoxaline derivatives, 2-(XYZC6H 2CHN-NH)-quinoxalines, 1, have been synthesized and evaluated for their activity against four cancer cell lines: potent cytotoxicities were found (IC50 ranging fro
