1559-45-1Relevant articles and documents
New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents
Chimichi, Stefano,Boccalini, Marco,Cosimelli, Barbara,Viola, Giampietro,Vedaldi, Daniela,Dall'Acqua, Francesco
, p. 7473 - 7476 (2002)
A new class of compounds analogues of geiparvarin is described: aldolic condensation of 3(2H)-furanones and 7-(2-oxoethoxy)coumarins followed by a very efficient dehydration protocol led to the title compounds which show good antitumoral activity against several human cell lines.
New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity
Chimichi, Stefano,Boccalini, Marco,Cosimelli, Barbara,Dall'Acqua, Francesco,Viola, Giampietro
, p. 5215 - 5223 (2007/10/03)
A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety.
REDUCTION OF Δ2-ISOXAZOLINES-2. A FACILE SYNTHESIS OF 3(2H)-FURANONES.
Curran, Dennis P.,Singleton, David H.
, p. 2079 - 2082 (2007/10/02)
A simple synthesis of the 3(2H)-furanone ring system is described.