156088-46-9

Basic information

• Product Name: 2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)-
• CAS NO: 156088-46-9
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Mol File: 156088-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)-(156088-46-9)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)-(156088-46-9)

Safety Data

• Hazardous Substances Data: 156088-46-9(Hazardous Substances Data)

Usage

General Description

"2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)-" is a chemical compound with the molecular formula C8H15NO2. It is also known as (5S)-5-(hydroxymethyl)-3,3-dimethyl-2-pyrrolidinone or (5S)-5-(Hydroxymethyl)pyrrolidin-2-one. 2-Pyrrolidinone, 5-(hydroxymethyl)-3,3-dimethyl-, (5S)- is a chiral molecule, meaning it has a non-superimposable mirror image. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It also has applications in the production of adhesives, coatings, and polymers due to its reactivity and versatility. Additionally, it is used as a solvent for a wide range of chemical reactions and processes.

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 443984-28-9 (S)-(N-benzyloxycarbonyl)-(4,4-dimethylpyrrolidin-2-yl)methan-1-ol 
• 212890-84-1 (S)-2-[(Diphenylphosphanyl)-methyl]-4,4-dimethyl-pyrrolidine 
• 212890-98-7 (S)-(+)-3,3-dimethyl-5-[((4-methylphenyl)sulfonyloxy)methyl]-1-benzylpyrrolidin-2-one 
• 212890-96-5 3,3-dimethyl-5-(2-oxanyloxymethyl)-1-benzylpyrrolidin-2-one 
• 212890-97-6 (S)-(+)-5-(hydroxymethyl)-3,3-dimethyl-1-benzylpyrrolidin-2-one 
• 184699-47-6 (S)-(-)-tert-butyl 4,4-dimethyl-2-[((4-methylphenyl)sulfonyloxy)methyl]pyrrolidinecarboxylate 
• 212890-87-4 (S)-(-)-tert-butyl 2-[(diphenylphosphino)methyl]-4,4-dimethylpyrrolidinecarboxylate 
• 184699-46-5 (S)-(+)-1,3,3-trimethyl-5-[((4-methylphenyl)sulfonyloxy)methyl]pyrrolidin-2-one 
• 212890-86-3 (S)-(-)-tert-butyl 2-(hydroxymethyl)-4,4-dimethylpyrrolidinecarboxylate 
• 473808-17-2 (S)-3,3-Dimethyl-1-(3-phenyl-propionyl)-5-trityloxymethyl-pyrrolidin-2-one 
• 163756-63-6 (5S)-(-)-3,3-dimethyl-5-triphenylmethoxymethyl-1-propionyl-pyrrolidin-2-one 
• 163756-62-5 (5S)-(-)-5-tert-butyldimethylsiloxymethyl-3,3-dimethyl-1-(3-phenylpropionyl)-pyrrolidin-2-one 
• 163756-70-5 (5R)-(-)-(1'-oxo-3'-phenylpropyl)-5-ethyl-3,3-dimethylpyrrolidin-2-one 
• 155956-28-8 (2'S,5R)-1-(1'-oxo-2'-phenylmethylpropyl)-3,3,5-trimethylpyrrolidin-2-one 

Relevant articles and documents

SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.

Synthesis of 5-substituted-3,3-dimethyl-2-pyrrolidinones: "Quat" chiral auxiliaries

The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in THF-water at 20°C.