156154-10-8

Basic information

• Product Name: 1,4-Benzodioxin, piperazine deriv.
• Synonyms: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-yl]carbonyl]-, monomethanesulfonate
• CAS NO: 156154-10-8
• Molecular Formula: MW:
• Molecular Weight: 0
• Mol File: 156154-10-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Benzodioxin, piperazine deriv.(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzodioxin, piperazine deriv.(156154-10-8)
• EPA Substance Registry System: 1,4-Benzodioxin, piperazine deriv.(156154-10-8)

Safety Data

• Hazardous Substances Data: 156154-10-8(Hazardous Substances Data)

Usage

Chemical origin

Derived from piperazine, a heterocyclic amine.

Core structure

Consists of a 1,4-benzodioxin core, which is a six-membered ring fused to a five-membered ring containing two oxygen atoms.

Molecular composition

A piperazine derivative with the benzodioxin core.

Pharmaceutical applications

Has potential pharmaceutical applications due to its pharmacological properties.

Serotonin receptor agonist

Studied for its potential as a serotonin receptor agonist, which may have implications for the treatment of various conditions.

Treatment of disorders

Investigated for its potential use in the treatment of neurological and psychiatric disorders.

Research interest

The chemical structure and properties of 1,4-Benzodioxin, piperazine deriv. make it a subject of interest for researchers and pharmaceutical companies.

Drug development

Its unique structure and properties are being explored for the development of new drugs targeting specific receptors and conditions.

Upstream product

• 75-75-2 methanesulfonic acid 
• 74191-85-8 doxazosin 
• 105314-71-4 (+)-Doxazosin hydrochloride 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 120-80-9 benzene-1,2-diol 
• 70918-54-6 (S)‐1,4‐benzodioxane‐2‐carboxylic acid 
• 401947-96-4 (S)-2,3-dihydrobenzo[1,4]dioxine-2-carbonyl chloride 
• 401941-54-6 (S)-N-(1,4-benzodioxan-2-carbonyl)piperazine 
• 3663-80-7 1,4-benzodioxane-2-carboxylic acid 
• 1246188-97-5 (2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(1H-imidazol-1-yl)methanone 

Relevant articles and documents

Process for the Preparation of Doxazosin and Salts Thereof

The present invention relates to a process for the preparation of doxazosin or salts thereof.

Conversion of modification D to modification A of doxazosin mesylate

A process for preparing doxazosin mesylate in modification A which comprises dissolving doxazosin with methanesulfonic acid in methanol or a mixture of an aprotic, polar organic solvent and methanol, removing any turbidity from the resulting solution, and

Practical chemical and enzymatic technologies for (S)-1,4-benzodioxan-2-carboxypiperizine intermediate in the synthesis of (S)-doxazosin mesylate

(S)-1,4-Benzodioxan-2-carboxypiperazine (S)-2, the key chiral intermediate for the synthesis of (S)-doxazosin, was prepared utilizing two approaches: (i) enzymatic resolution of ethyl 1,4-benzodioxan-2-carboxylate with an esterase (Serratia) followed by amide formation; (ii) direct resolution of 1,4-benzodioxan-2-carboxypiperazine 2 with D-tartaric acid. An efficient process for the conversion of (S)-2 to (S)-doxazosin mesylate was developed (80% yield, 99.9% e.e.).