15622-65-8 Usage
Description
MOLINDONE HYDROCHLORIDE (500 MG) is a light tan solid that serves as a D2 dopamine receptor antagonist and a monoamine oxidase (MAO) inhibitor. It is a pharmaceutical compound with antipsychotic properties, which makes it a valuable asset in the treatment of various mental health conditions.
Uses
Used in Pharmaceutical Industry:
MOLINDONE HYDROCHLORIDE (500 MG) is used as an antipsychotic agent for the treatment of schizophrenia and other psychotic disorders. It works by blocking dopamine receptors in the brain, which helps to alleviate the symptoms of these conditions.
MOLINDONE HYDROCHLORIDE (500 MG) is also used as a dopamine receptor antagonist for managing the symptoms of Tourette's syndrome and other hyperkinetic movement disorders. Its ability to modulate dopamine levels in the brain makes it an effective treatment option for these conditions.
Additionally, MOLINDONE HYDROCHLORIDE (500 MG) is used as a monoamine oxidase (MAO) inhibitor, which helps to increase the levels of certain neurotransmitters in the brain, such as serotonin, norepinephrine, and dopamine. This can be beneficial for individuals suffering from depression or other mood disorders.
Brand Name:
The brand name for MOLINDONE HYDROCHLORIDE (500 MG) is Moban, which is manufactured by Endo Pharmaceuticals.
Originator
Moban,Endo,US,1974
Manufacturing Process
Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2-
methyl-4-oxoindole.3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g
morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol)
were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to
dryness in vacuo on a steam bath and the residue digested with a mixture of
150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting
material was filtered off. To the acid solution, ammonia water was added
dropwise with stirring and the amine crystallized out. It was purified by
dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from
benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl-
4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.
Therapeutic Function
Antipsychotic
Check Digit Verification of cas no
The CAS Registry Mumber 15622-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,2 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15622-65:
(7*1)+(6*5)+(5*6)+(4*2)+(3*2)+(2*6)+(1*5)=98
98 % 10 = 8
So 15622-65-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H
15622-65-8Relevant articles and documents
PROCESS FOR PREPARATION OF MOLINDONE
-
, (2020/08/30)
The present invention provides process for preparation of molindone (I) comprising: a) reacting compound with cyclohexane-1,3-dione to form 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione wherein X is Cl, Br or I, b) cyclizing 2-(2-oxopentan-3-yl)cyclohexane-1,