156274-10-1

Basic information

• Product Name: 4-phenyl-3-(1-pyrrolyl)-2-thiophene-N-pyrrolidinocarboxamide
• CAS NO: 156274-10-1
• Molecular Weight: 322.431
• Mol File: 156274-10-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-phenyl-3-(1-pyrrolyl)-2-thiophene-N-pyrrolidinocarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-3-(1-pyrrolyl)-2-thiophene-N-pyrrolidinocarboxamide(156274-10-1)
• EPA Substance Registry System: 4-phenyl-3-(1-pyrrolyl)-2-thiophene-N-pyrrolidinocarboxamide(156274-10-1)

Safety Data

• Hazardous Substances Data: 156274-10-1(Hazardous Substances Data)

Upstream product

• 82437-64-7 methyl 3-amino-4-phenyl-2-thiophenecarboxylate 
• 140-29-4 phenylacetonitrile 
• 123-75-1 pyrrolidine 
• 156274-05-4 methyl 3-(1-pyrrolyl)-4-phenyl-2-thiophenecarboxylate 

Relevant articles and documents

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC50 = 15 nM) was shown to be a potent inhibitor of tubulin polymerization.