156397-47-6Relevant articles and documents
Synthesis and reactivity of bis(diphenylphosphino)amine-bridged heterobimetallic iron-platinum μ-isonitrile and μ-aminocarbyne complexes Dedicated to Prof. Jacques Amaudrut on the occasion of his 75th birthday.
Knorr, Michael,Jourdain, Isabelle,Mohamed, Ahmed Said,Khatyr, Abderrahim,Koller, Stephan G.,Strohmann, Carsten
, p. 70 - 85 (2015)
Reaction of [(OC)3Fe(μ-CO)(μ-dppa)Pt(PPh3)] (1) (dppa = bis(diphenylphosphino)amine) with various isonitriles in a 1:1 or 1:2 ratio yields the isonitrile-bridged compounds [(OC)3Fe(μ-CN-R)(μ-dppa)Pt(PPh3)] (2) a
A Highly Efficient Gold(I)-Catalyzed Mukaiyama-Mannich Reaction of α-Amino Sulfones with Fluorinated Silyl Enol Ethers to Give β-Amino α-Fluorinated Ketones
Hu, Xiao-Si,Du, Yi,Yu, Jin-Sheng,Liao, Fu-Min,Ding, Pei-Gang,Zhou, Jian
, p. 2194 - 2198 (2017)
Ph 3 PAuOTf was identified as a powerful catalyst for the Mukaiyama-Mannich reaction of fluorinated silyl enol ethers with α-amino sulfones. This provides ready access to β-amino α-fluorinated ketones in good to excellent yields.
Cationic Au(I) complexes with aryl-benzothiazoles and their antibacterial activity
Stenger-Smith, Jenny,Chakraborty, Indranil,Mascharak, Pradip K.
, p. 80 - 85 (2018)
Two cationic Au(I) complexes derived from aryl-benzothiazoles, namely [(PPh3)Au(pbt)](OTf) (1) and [(PPh3)Au(qbt)](OTf) (2) (where pbt = 2?(pyridyl)benzothiazole and qbt = (quinolyl)benzothiazole, and OTf? = trifluorometha
Pt-M (M = Au and Tl) Dative Bonds Using Bis(cyclometalated)platinum(II) Complexes
Rajabi, Sheida,Jamali, Sirous,Naseri, Soroosh,Jamjah, Ali,Kia, Reza,Samouei, Hamidreza,Mastrorilli, Piero,Shahsavari, Hamid R.,Raithby, Paul R.
, p. 1709 - 1720 (2019)
Symmetrical and unsymmetrical biscyclometalated platinum(II) complexes [Pt(ptpy)2], 1, and [Pt(ptpy)(bppy)], 2, in which ptpy = deprotonated 2-(p-tolyl)pyridine and bppy = deprotonated 2-(3-bromophenyl)pyridine, have been prepared from the reac
Gold-Catalyzed Amide/Carbamate-Linked N, O-Acetal Formation with Bulky Amides and Alcohols
Ohsawa, Kosuke,Ochiai, Shota,Kubota, Junya,Doi, Takayuki
, p. 1281 - 1291 (2021/01/14)
A gold-catalyzed N,O-acetal formation was established to construct an amide/carbamate-linked N,O-acetal substructure with bulky alcohols. The acyliminium cation species generated from o-alkynylbenzoic acid ester in the presence of a gold catalyst is highly reactive and underwent nucleophilic attack of various bulky alcohols and phenols at room temperature under neutral conditions, leading to the corresponding N,O-acetals in yields of 34-89% with good functional group tolerance.
Synthesis of new thiourea-metal complexes with promising anticancer properties
Canudo-Barreras, Guillermo,Gimeno, M. Concepción,Herrera, Raquel P.,Izaga, Anabel,Marzo, Isabel,Ortego, Lourdes
, (2021/11/27)
In this work, two thiourea ligands bearing a phosphine group in one arm and in the other a phenyl group (T2) or 3,5-di-CF3 substituted phenyl ring (T1) have been prepared and their coordination to Au and Ag has been studied. A different behavior is observed for gold complexes, a linear geometry with coordination only to the phosphorus atom or an equilibrium between the linear and three-coordinated species is present, whereas for silver complexes the coordination of the ligand as P?S chelate is found. The thiourea ligands and their complexes were explored against different cancer cell lines (HeLa, A549, and Jurkat). The thiourea ligands do not exhibit relevant cytotoxicity in the tested cell lines and the coordination of a metal triggers excellent cytotoxic values in all cases. In general, data showed that gold complexes are more cytotoxic than the silver compounds with T1, in particular the complexes [AuT1(PPh3)]OTf, the bis(thiourea) [Au(T1)2 ]OTf and the gold-thiolate species [Au(SR)T1]. In contrast, with T2 better results are obtained with silver species [AgT1(PPh3)]OTf and the [Ag(T1)2 ]OTf. The role played by the ancillary ligand bound to the metal is important since it strongly affects the cytotoxic activity, being the bis(thiourea) complex the most active species. This study demonstrates that metal complexes derived from thiourea can be biologically active and these compounds are promising leads for further development as potential anticancer agents.
Hydrogen-Bonding-Assisted Exogenous Nucleophilic Reagent Effect for β-Selective Glycosylation of Rare 3-Amino Sugars
Zeng, Jing,Wang, Ruobin,Zhang, Shuxin,Fang, Jing,Liu, Shanshan,Sun, Guangfei,Xu, Bingbing,Xiao, Ying,Fu, Dengxian,Zhang, Wenqi,Hu, Yixin,Wan, Qian
supporting information, p. 8509 - 8515 (2019/06/13)
Challenges for stereoselective glycosylation of deoxy sugars are notorious in carbohydrate chemistry. We herein report a novel strategy for the construction of the less investigated β-glycosidic bonds of 3,5-trans-3-amino-2,3,6-trideoxy sugars (3,5-trans-3-ADSs), which constitute the core structure of several biologically important antibiotics. Current protocol leverages a C-3 axial sulfonamide group in 3,5-trans-3-ADSs as a hydrogen-bond (H-bond) donor and repurposes substoichiometric phosphine oxide as an exogenous nucleophilic reagent (exNu) to establish an intramolecular H-bond between the former and the derived α-oxyphosphonium ion. This pivotal interaction stabilizes the α-face-covered intermediate to inhibit the formation of the more reactive β-intermediate, thereby yielding reversed β-selectivity, which is unconventional for an exNu-mediated glycosylation system. A wide range of substrates was accommodated, and good to excellent β-selectivities were ensured by this H-bonding-assisted exNu effect. The robustness of the current strategy was further attested by the architectural modification of natural products and drugs containing 3,5-trans-3-ADSs, as well as the synthesis of a trisaccharide unit in avidinorubicin.
