156640-15-2Relevant articles and documents
POTENTIAL NOOTROPIC AGENTS: SYNTHESIS OF SOME 1,4-DISUBSTITUTED 2-OXOPYRROLIDINES AND SOME RELATED COMPOUNDS
Valenta, Vladimir,Urban, Jiri,Taimr, Jan,Polivka, Zdenek
, p. 1126 - 1136 (2007/10/02)
4-(Aminomethyl)-1-benzyl-2-oxopyrrolidine (VI) was transformed by treatment with (4-benzhydrylpiperazin-1-yl)carbonyl chlorides IIIb-IIId and with (4-methylpiperazin-1-yl)carbonyl chloride (IIIa) to the carboxamides IVa-IVd.Heating of 1-(ethoxycarbonylmethyl)-2,4-dioxopyrrolodine (XIX) in acetonitrile in the presence of water afforded XVIIIa.Treatment with ammonia led to the diamide XVIIIc, while alkaline hydrolysis of XVIIIa gave the dicarboxylic acid XVIIIb. 4-(Aminomethyl)-1-(4-methylthiobenzyl)-2-oxopyrrolidine (XII) was prepared by the reaction of 4-(methylthio)benzylamine with itaconic acid and the following sequence of reaction ...