156731-34-9Relevant articles and documents
PCSK9 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 143-144, (2020/07/31)
The invention relates to a novel inhibitor pharmacophore of PCSK9 and heteroaryl compounds that bind the PCSK9 protein.
Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry
Zaed, Ahmed M.,Grafton, Mark W.,Ahmad, Sajjad,Sutherland, Andrew
, p. 1511 - 1515 (2014/03/21)
A highly efficient one-pot multistep process involving an asymmetric Pd(II)-catalyzed Overman rearrangement and a Ru(II)-catalyzed ring-closing metathesis reaction has been developed for the preparation of (R)- or (S)-aminocyclopenta-2-enes. The rapid strategy employed and the relatively mild conditions of the one-pot process allowed the multigram synthesis of the carbocycles in high enantiomeric excess (92% ee). The synthetic utility of these compounds was demonstrated by the stereoselective incorporation of hydroxyl groups, generating cis-4- and cis-5-aminocyclopenta-2-en-1-ols, important building blocks for medicinal chemistry.
Asymmetric Catalysis by Vitamin B12: The Isomerization of Achiral Aziridines to Optically Active Allylic Amines
Zhang, Zhong da,Scheffold, Rolf
, p. 2602 - 2615 (2007/10/02)
Achiral N-acylaziridines are isomerized to optically active N-acyl-allylamines in ee's of up to 95percent by catalytic amounts of cob(I)alamin in MeOH.