156868-84-7 Usage
Description
1-(3-Bromopropyl)-3-fluorobenzene, with the chemical formula C9H9BrF, is a clear, colorless liquid that serves as a crucial intermediate in the synthesis of various compounds, including pharmaceuticals, agrochemicals, dyes, polymers, and other organic chemicals. Its structure and properties make it a versatile building block in the chemical industry, despite its classification as a hazardous material that requires careful handling to prevent skin and eye irritation, as well as potential respiratory and central nervous system effects.
Uses
Used in Pharmaceutical Industry:
1-(3-Bromopropyl)-3-fluorobenzene is used as a synthetic intermediate for the development of new pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the advancement of drug discovery and therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(3-Bromopropyl)-3-fluorobenzene is utilized as a key component in the synthesis of various agrochemicals. Its role in this industry is essential for the development of new pesticides, herbicides, and other agricultural products that help improve crop yields and protect plants from pests and diseases.
Used in Dye Production:
This chemical compound is also employed in the production of dyes, where its specific properties enable the creation of a diverse array of colorants used in various industries, such as textiles, plastics, and printing.
Used in Polymer Industry:
1-(3-Bromopropyl)-3-fluorobenzene is used as a building block in the synthesis of polymers, which are essential materials in numerous applications, including packaging, automotive, electronics, and construction. Its incorporation into polymer chemistry allows for the development of new materials with improved properties and performance.
Used in Organic Chemicals Synthesis:
1-(3-BroMopropyl)-3-fluorobenzene is also used in the synthesis of a variety of other organic chemicals, further highlighting its versatility and importance in the chemical industry. Its role in this context is vital for the development of new chemicals with potential applications in various fields, such as materials science, environmental science, and biotechnology.
It is crucial to follow proper safety protocols when working with 1-(3-Bromopropyl)-3-fluorobenzene to minimize the risk of exposure and adverse health effects, given its classification as a hazardous material.
Check Digit Verification of cas no
The CAS Registry Mumber 156868-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,8,6 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 156868-84:
(8*1)+(7*5)+(6*6)+(5*8)+(4*6)+(3*8)+(2*8)+(1*4)=187
187 % 10 = 7
So 156868-84-7 is a valid CAS Registry Number.
156868-84-7Relevant articles and documents
Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity
Yamashita, Yasunobu,Tanaka, Ken-ichiro,Yamakawa,Asano,Kanda, Yuki,Takafuji,Kawahara, Masahiro,Takenaga, Mitsuko,Fukunishi, Yoshifumi,Mizushima
supporting information, p. 3339 - 3346 (2019/06/18)
The treatment for patients with chronic obstructive pulmonary disease (COPD) usually involves a combination of anti-inflammatory and bronchodilatory drugs. We recently found that mepenzolate bromide (1) and its derivative, 3-(2-hydroxy-2, 2-diphenylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (5), have both anti-inflammatory and bronchodilatory activities. We chemically modified 5 with a view to obtain derivatives with both anti-inflammatory and longer-lasting bronchodilatory activities. Among the synthesized compounds, (R)-(–)-12 ((R)-3-(2-hydroxy-2,2-diphenylacetoxy)-1-(3-phenylpropyl)-1-azoniabicyclo[2.2.2]octane bromide) showed the highest affinity in vitro for the human muscarinic M3 receptor (hM3R). Compared to 1 and 5, (R)-(–)-12 exhibited longer-lasting bronchodilatory activity and equivalent anti-inflammatory effect in mice. The long-term intratracheal administration of (R)-(–)-12 suppressed porcine pancreatic elastase-induced pulmonary emphysema in mice, whereas the same procedure with a long-acting muscarinic antagonist used clinically (tiotropium bromide) did not. These results suggest that (R)-(–)-12 might be therapeutically beneficial for use with COPD patients given the improved effects seen against both inflammatory pulmonary emphysema and airflow limitation in this animal model.
SYNTHESIS AND UTILIZATION OF SMALL MOLECULES FOR THE TREATMENT OF INFLAMMATION ASSOCIATED WITH INTERLEUKIN-1 SIGNALING
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Page/Page column 11-12; 2/2, (2010/04/03)
The invention describes synthetic compounds, methods of preparation and their uses thereof an anti-inflammatory compounds that reduce inflammation associated with interleukin-1signaling.
3-SUBSTITUTED-[1,2,3]BENZOTRIAZINONE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES
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Page/Page column 83-84, (2008/12/07)
This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
