157437-24-6 Usage
Description
(2,2-difluoro-1,3-benzodioxol-4-yl)acetonitrile is a chemical compound with the molecular formula C9H5F2NO2. It is a nitrile derivative of benzodioxole, a compact organic molecule with a five-membered ring fused to a six-membered ring containing two oxygen atoms. The presence of fluorine atoms in the molecule can make it useful in drug discovery and development due to their unique chemical properties.
Uses
Used in Pharmaceutical Industry:
(2,2-difluoro-1,3-benzodioxol-4-yl)acetonitrile is used as a building block in the synthesis of various drugs and pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Research and Development:
(2,2-difluoro-1,3-benzodioxol-4-yl)acetonitrile is used in research and development for its potential medicinal properties. Its unique chemical structure and the presence of fluorine atoms make it a promising candidate for further exploration and application in the field of medicine.
It is important to handle and use this chemical with caution, as it may possess certain hazards and risks associated with its handling and exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 157437-24-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,4,3 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 157437-24:
(8*1)+(7*5)+(6*7)+(5*4)+(4*3)+(3*7)+(2*2)+(1*4)=146
146 % 10 = 6
So 157437-24-6 is a valid CAS Registry Number.
157437-24-6Relevant articles and documents
A homologous series of O- and N-functionalized 2,2-difluoro-1,3-benzodioxoles: An exercise in organometallic methodology
Schlosser, Manfred,Gorecka, Joanna,Castagnetti, Eva
, p. 452 - 462 (2007/10/03)
The conversion of 2,2-difluoro-1,3-benzodioxole, an exceptionally acidic arene, via a 4-lithiated intermediate into more than three dozen new derivatives was conceived as a case study. The lithiated species was trapped by C0-electrophiles (4-toluenesulfonyl azide, fluorodimethoxyborane, iodine), C1-electrophiles (carbon dioxide, N,N-dimethylformamide, formaldehyde, dimethyl sulfate), C2-electrophiles (oxalic acid diesters, oxirane), C3-electrophiles (oxetane), and higher alkyl iodides. The resulting carboxylic acid 1a may be treated with organolithium compounds to afford ketones (e.g. 10) and the aldehyde 9 can be condensed with nitromethane or acetic anhydride under basic conditions. If not oxidized with chromium trioxide to the corresponding carboxylic acids, the alcohols 2b, 2c, and 2d can be transformed into the corresponding bromides (12) or sulfonates (13). Their condensation with nitrogen-containing C0-nucleophiles (hydroxylamine, sodium azide, potassium phthalimide), C1-nucleophiles (potassium cyanide), and C2-nucleophiles (aceto-nitrile) opens a convenient access to the amines 3. Other reactions gave, despite a proven track record in other areas, only moderate yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
