1576-59-6

Basic information

• Product Name: 2-amino-5-bromobenzenesulfonic acid
• Synonyms: 2-amino-5-bromobenzenesulfonic acid
• CAS NO: 1576-59-6
• Molecular Weight: 252.089
• Mol File: 1576-59-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-5-bromobenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-bromobenzenesulfonic acid(1576-59-6)
• EPA Substance Registry System: 2-amino-5-bromobenzenesulfonic acid(1576-59-6)

Safety Data

• Hazardous Substances Data: 1576-59-6(Hazardous Substances Data)

Upstream product

• 53218-26-1 6-bromo-1,3-benzothiazole 
• 106-40-1 4-bromo-aniline 
• 7647-01-0 hydrogenchloride 
• 860513-33-3 5-bromo-2-ureido-benzenesulfonic acid 
• 41363-39-7 2-carboxamidebenzenesulfonic acid 
• 88-21-1 2-amino-1-benzenesulfonic acid 
• 7732-18-5 water 
• 7726-95-6 bromine 
• 103-88-8 4-bromoacetanilide 

Downstream Products

• 171664-63-4 4-iodo-2-sulfo-benzenediazonium-betaine 
• 860512-69-2 2-ureido-benzenesulfonic acid 
• 171664-62-3 2-amino-5-iodo-benzenesulfonic acid 
• 697-87-0 2,4-dibromo-6-iodoaniline 
• 28584-90-9 N,N'-bis phenyl imidodicarbonic diamide 
• 147-82-0 2,4,6-tribromoaniline 
• 88-21-1 2-amino-1-benzenesulfonic acid 
• 860513-35-5 5-bromo-2-(N'-carbamoyl-ureido)-benzenesulfonic acid 

Relevant articles and documents

A new bromine-containing reagent for cysteine modification

5-Bromo-2[(2-iodoacetyl)amino]benzenesulfonic acid (AIBSA), a reagent for modification of free of cysteine thiol groups in proteins and peptides, was synthesized. Rate constants of its interaction with thiol groups were determined. The presence of a bromi

SSR182289A, a selective and potent orally active thrombin inhibitor

SSR182289A 1 is the result of a rational optimisation process leading to an orally active thrombin inhibitor. The structure incorporates an original 2-(acetylamino)-[1,1′-biphenyl]-3-sulfonyl N-terminal motif, a central L-Arg surrogate carrying a weakly basic 3-amino-pyridine, and an unusual 4-difluoropiperidine at the C-terminus. Its synthesis is convergent and palladium catalysis has been employed for the construction of the key C-C bonds: Suzuki coupling for the bis-aryl fragment and Sonogashira reaction for the δ-ε bond of the central amino-acid chain. The compound is a potent inhibitor of thrombin's activities in vitro and demonstrates potent oral anti-thrombotic potencies in three rat models of thrombosis. The observed in vitro potency could be rationalized through the examination of the interactions within the SSR182289A 1 - thrombin crystal structure. SSR182289A 1, has been therefore selected for further development.