157665-51-5

Basic information

• Product Name: 3-FLUORO-4-NITROBENZOYL CHLORIDE
• Synonyms: 3-FLUORO-4-NITROBENZOYL CHLORIDE;4-(Chlorocarbonyl)-2-fluoronitrobenzene, 4-(Chloroformyl)-2-fluoronitrobenzene
• CAS NO: 157665-51-5
• Molecular Formula: C₇H₃ClFNO₃
• Molecular Weight: 203.56
• Mol File: 157665-51-5.mol
• Article Data: 31

Chemical Properties

• Melting Point: 23-25
• Appearance: /
• CAS DataBase Reference: 3-FLUORO-4-NITROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-NITROBENZOYL CHLORIDE(157665-51-5)
• EPA Substance Registry System: 3-FLUORO-4-NITROBENZOYL CHLORIDE(157665-51-5)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 157665-51-5(Hazardous Substances Data)

Usage

Description

3-Fluoro-4-nitrobenzoyl chloride is an organic compound characterized by its molecular structure that features a benzene ring with a fluorine atom at the 3-position and a nitro group at the 4-position. The molecule also contains a benzoyl chloride functional group, which is a key component in various chemical reactions. 3-FLUORO-4-NITROBENZOYL CHLORIDE is known for its reactivity and is commonly utilized in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-nitrobenzoyl chloride is used as a reactant for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of new molecules with potential therapeutic properties, contributing to the development of novel drugs for treating various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Fluoro-4-nitrobenzoyl chloride is employed as a reagent in the production of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, ultimately leading to increased crop yields and improved food security.
Used in Organic Synthesis:
3-Fluoro-4-nitrobenzoyl chloride is also used as a key intermediate in organic synthesis, allowing chemists to create a wide range of specialty chemicals with diverse applications. These can include dyes, polymers, and other materials with specific properties that are valuable in various industries.
Overall, 3-Fluoro-4-nitrobenzoyl chloride is a versatile compound with a broad range of applications across different industries, primarily due to its unique molecular structure and reactivity. Its use as a reactant or reagent in various organic reactions has led to the development of new and innovative products, making it an important component in the fields of pharmaceuticals, agrochemicals, and organic synthesis.

Upstream product

• 403-21-4 3-fluoro-4-nitrobenzoic acid 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 85803-26-5 di-tert-butyl N-(3-fluoro-4-nitrobenzoyl)-l-glutamate 
• 157665-52-6 3-fluoro-4-nitrobenzoic acid t-butyl ester 
• 194809-27-3 N-(3-fluoro-4-nitrobenzoyl)-(αS,γR)-γ-fluoroglutamic acid α,γ-diisopropyl ester 
• 194809-30-8 N-(3-fluoro-4-nitrobenzoyl)-(αS,γS)-γ-fluoroglutamic acid α,γ-diisopropyl ester 
• 552832-89-0 (3-fluoro-4-nitro-phenyl)-pyrrolidin-1-yl-methanone 
• 3556-52-3 3-fluoro-4-nitro-benzamide 
• 695186-52-8 methyl [3-(3-fluoro-4-nitro benzoylamino)-4-hydroxy-phenyl] acetate 
• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 
• 855869-58-8 2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(pyrrolidine-1-carbonyl)-phenyl]-amide 
• 218298-94-3 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenyl-aminocarbonyl]pyrazole 
• 209960-85-0 (4-amino-3-fluorophenyl)pyrrolidin-1-ylmethanone 
• 552832-90-3 1-(4-chloro-3-nitro-phenyl)-1H-tetrazole-5-carboxylic acid [2-fluoro-4-(pyrrolidine-1-carbonyl)-phenyl]-amide 
• 194809-31-9 N-(4-amino-3-fluorobenzoyl)-(αS,γS)-γ-fluoroglutamic acid α,γ-diisopropyl ester 
• 194809-28-4 N-(4-amino-3-fluorobenzoyl)-(αS,γR)-γ-fluoroglutamic acid α,γ-diisopropyl ester 

Relevant articles and documents

Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors

Cathepsin K is a major drug target for osteoporosis and related-bone disorders. Using a combination of virtual combinatorial chemistry, QSAR modeling, and molecular docking studies, a series of cathepsin K inhibitors based on N-(functionalized benzoyl)-homocycloleucyl-glycinonitrile scaffold was developed. In order to avoid previous problems of cathepsin K inhibitors associated with lysosomotropism of compounds with basic character that resulted in off-target effects, a weakly- to nonbasic moiety was incorporated into the P3 position. Compounds 5, 6, and 9 were highly selective for cathepsin K when compared with cathepsins L and S, with the Ki values in the 10-30 nM range. The kinetic studies revealed that the new compounds exhibited reversible tight binding to cathepsin K, while the X-ray structural studies showed covalent and noncovalent binding between the nitrile group and the catalytic cysteine (Cys25) site.

sEH Inhibitor or pharmaceutically acceptable composition thereof as well as preparation method and application thereof

The invention provides sEH inhibitor or a pharmaceutically acceptable composition and a preparation method and application thereof, and belongs to the technical field of medicines. sEH Inhibitor or a pharmaceutically acceptable composition thereof according to the present invention is provided, and the sEH inhibitor has the structure shown I. sEH Inhibitor provided by the invention can stabilize an endogenous substance epoxy fatty acid with wide physiological activity, has a strong inhibition effect on human recombinant sEH, and can be used for regulating the generation of a plurality of pro-inflammatory cytokines. The invention relieves the stress of endoplasmic reticulum, prevents or reverses the dysfunction of endothelial dysfunction, stabilizes mitochondria function multiple action mechanisms to obviously relieve neuropathic pain, and can effectively avoid adverse reactions related to the target spot. Furthermore, the sEH inhibitor structure provided by the invention does not contain free carboxyl groups, can avoid adverse reactions such as gastrointestinal irritation caused by oral administration, and is small in adverse reaction, high in bioavailability, excellent in analgesic effect and small in administration amount.

SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: (Formula AA) or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.