158112-55-1Relevant articles and documents
An improved preparation of 5'-deoxyadenosine by coupling methods
Lerner, Leon M.
, p. 250 - 253 (1988)
-
A three-acetyl deoxyribose α isomer preparation method
-
Paragraph 0013; 0014, (2019/07/04)
The invention discloses a capecitabine intermediate impurity tri acetyl deoxyribose α isomer: the chemical name is 1 α - 1, 2, 3 - three-acetoxy - 5 - deoxy - D - ribose of the preparation method. The preparation method in order to 5 - deoxy - D - ribose as a synthetic raw material, by isopropenyl acetate/iron trichloride acetylation than three acetyl deoxyribose α isomer crude, passes through the column again chromatography purification to obtain the triacetyl deoxyribose α isomer pure product. The invention provides a triacetyl deoxyribose α isomer preparation method, with simple operation, the advantage of the high product purity, for capecitabine intermediate and the quality of the finished good foundation for the study.
NOVEL PROCESS FOR THE RECOVERY OF BETA ACETYLFURANOSIDE
-
Page/Page column 3, (2010/08/07)
There is provided an improved method for the recovery of residual, unseparated β-ACF from reaction mixtures remaining from an initial synthesis of ACF, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.
PREPARATION OF CAPECITABINE
-
Page/Page column 21; 22; 23, (2010/06/20)
The present invention relates to substantially pure capecitabine and processes for the preparation thereof.